EC Number   |
General Information |
Reference |
|---|
  1.8.4.11 | drug target |
astragaloside IV protects PC-12 cells from 1-methyl-4-phenylpyridinium-induced oxidative damage through upregulating MsrA. Astragaloside IV may serve as an effective therapeutic agent for aging and Parkinson's disease |
764644 |
| 1.8.4.11 | malfunction |
enzyme-deficient mice are more susceptible to kidney ischemia/reperfusion injury than wild type mice. Deletion of the enzyme enhances renal functional and morphological impairments, congestion, inflammatory responses, and oxidative stress under ischemia/reperfusion conditions |
723957 |
| 1.8.4.11 | malfunction |
lack of or overexpression of MsrA in cells affects the function of proteins and can lead to altered cellular processes |
764709 |
| 1.8.4.11 | malfunction |
MsrA deficiency increases both basal and acetaminophen-induced thioredoxin reductase 1 expression levels, likely through increased Nrf2 activation. Conversely, MsrA overexpression diminishes the augmented thioredoxin reductase 1 levels in acetaminophen-treated MsrA(-/-) hepatocytes, reducing susceptibility against acetaminophen-induced cytotoxicity |
764065 |
| 1.8.4.11 | malfunction |
MsrA-/- mice are more susceptible to lipopolysaccharide (LPS) induced lethal shock than wild-type (MsrA+/+) mice. Serum levels of the proinflammatory cytokines IL-6 and TNF-alpha induced by LPS are higher in MsrA-/- than in MsrA+/+ mice. MsrA deficiency in the bone marrow-derived macrophages (BMDMs) also increases the LPS-induced cytotoxicity as well as TNF-alpha level. Basal and LPS-induced reactive oxygen species (ROS) levels are higher in MsrA-/- than in MsrA+/+ bone marrow-derived macrophages. Phosphorylation levels of p38, JNK, and ERK are higher in MsrA-/- than in MsrA+/+ BMDMs in response to LPS, suggesting that MsrA deficiency increases MAPK activation. MsrA deficiency increased the expression and nuclear translocation of NF-kappaB and the expression of inducible nitric oxide synthase, a target gene of NF-kappaB, in response to lipopolysaccharide (LPS) |
764011 |
| 1.8.4.11 | malfunction |
the msrA gene deletion (DELTAmsrA) strain shows reduced (60%) malate synthase specific activity |
764218 |
| 1.8.4.11 | metabolism |
HeLa cells pretreated with MsrA secrete reduced levels of TNF-alpha following Mycoplasma genitalium infection. MsrA treatment of cells affects the phosphorylation status of transcriptional regulators such as NF-kappaB, JNK and p53 that regulate different cytokines |
764709 |
| 1.8.4.11 | metabolism |
methionine sulfoxide reductase A is an essential enzyme in the antioxidant system which scavenges reactive oxygen species through cyclic oxidation and reduction of methionine and methionine sulfoxide |
725480 |
| 1.8.4.11 | metabolism |
MsrA expression is dependent on the Sirt1-FOXO3a signaling pathway |
764644 |
| 1.8.4.11 | metabolism |
the enzyme participates in regulating methionine metabolism and the trans-sulfuration pathway under normal and ischemia/reperfusion conditions |
723957 |
