EC Number   |
General Information |
Reference |
|---|
    2.7.1.36 | evolution |
GbAACT and GbMVK are highly homologous to AACT genes and MVK genes from other plant species. The structure of GbMVK monomer contains a ribosomal protein S5 2-type (8-230), a GHMP kinase N-terminal domain (140-220), and a GHMP kinase C-terminal domain (236-390). Ile146-Ala157 is an ATP-binding conserved site. Molecular evolution analysis and phylogenetic analysis, overview |
757716 |
| 2.7.1.36 | malfunction |
a mevalonate kinase heterozygous missense mutation C152Y in a patient with disseminated superficial actinic porokeratosis is detected. Disseminated superficial actinic porokeratosis (DSAP) is a genodermatosis with autosomal dominant inheritance and near-complete penetrance clinically featuring uniform 3- to 7-mm annular lesions with scaly borders on sun-exposed face and extremities. The hyperkeratotic rim correlates histopathologically with the presence of a cornoid lamella |
759694 |
| 2.7.1.36 | malfunction |
mutations in the mevalonate kinase gene cause the hyperimmunoglobulin D syndrome, HIDS, an autosomal recessive autoinflammatory disease |
709706 |
| 2.7.1.36 | metabolism |
ginkgolides and bilobalides, collectively termed terpene trilactones (TTLs), are terpenoids that form the main active substance of Ginkgo biloba. Terpenoids in the mevalonate (MVA) biosynthetic pathway include acetyl-CoA C-acetyltransferase (AACT) and mevalonate kinase (MVK) as core enzymes, pathways overview. TTL content in Ginkgo biloba can be enhanced by upregulating the transcript levels of some of these genes |
757716 |
| 2.7.1.36 | metabolism |
mevalonate kinase (MK) is a key enzyme of the mevalonate pathway, which produces the biosynthetic precursors for steroids, including cholesterol, and isoprenoids, the largest class of natural products |
760041 |
| 2.7.1.36 | metabolism |
MVK functions downstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA) in the mevalonate pathway. The mevalonate pathway provides crucial molecules to cells, and may be an important metabolic pathway in human skin. Short-chain isoprenoids farnesyl diphosphate (FPP) and geranylgeranyl diphosphate (GGPP) are the intermediate products of the mevalonate pathway, these attach to small G proteins covalently, and serve as molecular switches in many biochemical pathways |
759158 |
| 2.7.1.36 | metabolism |
the enzyme is part of the mevalonate pathway leading to the production of farnesyl diphosphate and geranylgeranyl diphosphate, overview |
708647 |
| 2.7.1.36 | metabolism |
the enzyme is regulating the mevalonate pathway in Streptococcus pneumoniae, it is strongly feedback-inhibited by diphosphomevalonate, the penultimate compound in the pathway, overview |
707737 |
| 2.7.1.36 | metabolism |
the mevalonate pathway is an essential part of isoprenoid biosynthesis leading to production of a diverse class of over 30000 biomolecules including cholesterol, heme, and all steroid hormones. In trypanosomatids, the mevalonate pathway also generates dolichols, which play an essential role in construction of glycosylphosphatidylinositol (GPI) molecules that anchor variable surface proteins (VSGs) to the plasma membrane. Isoprenoid biosynthesis involves one of the most highly regulated enzymes in nature, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), which catalyzes the conversion of HMG-CoA to mevalonic acid. The enzyme mevalonate kinase (MVK) subsequently converts mevalonic acid to 5-phosphomevalonic acid. Presence of mevalonate pathway enzymes in vivo in Trypanosoma evansi during the course of infection |
-, 759225 |
| 2.7.1.36 | metabolism |
the mevalonate pathway is an important metabolic pathway that provides cells with bioactive molecules essential for multiple cellular processes |
759224 |
