EC Number   |
General Information |
Reference |
|---|
    4.1.1.37 | malfunction |
hepatoerythropoietic porphyria results from a deficiency of uroporphyrinogen decarboxylase |
714636 |
| 4.1.1.37 | malfunction |
humans deficient in UROD present with porphyria cutanea tarda, a condition characterized by light-sensitive dermatitis, excretion of excess uroporphyrins, and associated hepatic porphyrin accumulation |
728637 |
| 4.1.1.37 | malfunction |
UROD knockdown plus radiation induces caspase-mediated apoptosis and cell cycle arrest in head and neck cancer cells in vitro and suppresses the in vivo tumor-forming capacity of head and neck cancer cells, as well as delays the growth of established tumor xenografts in mice |
716915 |
| 4.1.1.37 | metabolism |
UROD is a key regulator of heme biosynthesis |
716915 |
| 4.1.1.37 | metabolism |
uroporphyrinogen decarboxylase, Hem12p, is involved in the 5th step of heme biosynthesis in the cytosol, before biosynthesis is completed within mitochondria |
728426 |
