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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 4.2.1.103metabolism isonitrile hydratase is involved in the first step of isonitrile metabolism hydrating isonitrile to the corresponding N-substituted formamide -, 715552
Display the word mapDisplay the reaction diagram Show all sequences 4.2.1.103physiological function isocyanide hydratase is an enzyme of the DJ-1 superfamily that hydrates isocyanides to yield the corresponding N-formamide, structural basis for catalysis, overview. ICH contains a highly conserved Cys101 that is required for catalysis and interacts with Asp17, Thr102, and an ordered water molecule in the active site. Asp17 activates the ordered water molecule to hydrate organic isocyanides. The thiolate of Cys101 is proposed to be a critical nucleophile that initiates the hydration of isocyanides -, 715542
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