EC Number   |
General Information |
Reference |
|---|
   5.4.99.17 | evolution |
enzyme distribution in the different taxa, overview |
726715 |
| 5.4.99.17 | evolution |
squalene hopene cyclases are class II triterpene synthases that use a proton-initiated cationic polycyclization cascade to form carbopolycyclic products. The class II mechanism involves the Broensted acid sequence motif DxDD, catalytic mechanism compared to terpene cyclases, overview |
727345 |
| 5.4.99.17 | evolution |
structure-function relationships of squalene-hopene cyclases, the DXDD motif, which is typical for all squalene-hopene cyclases, overview |
726715 |
| 5.4.99.17 | malfunction |
inactivation of slr2089 leads to accumulation of squalene to a level over 70times higher than in wild-type cells, but no significant growth deficiency in the DELTAshc strain occur compared to the wild-type Synechocystis even at high light conditions |
728638 |
| 5.4.99.17 | metabolism |
the enzyme converts squalene into hopene, the substrate for forming hopanoids |
728638 |
| 5.4.99.17 | metabolism |
the enzyme converts squalene to hopanol, EC 4.2.1.129, and to hopene, EC 5.4.99.17, but not to tetrahymanol, EC 4.2.1.123, pathway overview |
726715 |
| 5.4.99.17 | metabolism |
the enzyme converts squalene to tetrahymanol, EC 4.2.1.123, to hopene, EC 5.4.99.17, and to hopanol, EC 4.2.1.129, pathway overview |
726715 |
| 5.4.99.17 | metabolism |
the enzyme is involved in biosynthesis of hopanoids, members of a large group of cyclic triterpenoic compounds that have important functions in many prokaryotic and eukaryotic organisms |
726715 |
| 5.4.99.17 | metabolism |
the nezym eis involved in biosynthesis of hopanoids, members of a large group of cyclic triterpenoic compounds that have important functions in many prokaryotic and eukaryotic organisms |
726715 |
| 5.4.99.17 | more |
structure-function relationships of SHCs, active site structure, overview |
726715 |
