EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
INS-1 cell |
pancreatic islet beta-cell, suppression of enzyme activity by small interfering RNA results in impairment of glucose-stimulated insulin secretion, attenuates glucose-induced increments in pyruvate cycling activity and in NADPH levels, and causes increases in lactate production |
669494 |
1.14.11.4 | procollagen-lysine 5-dioxygenase |
INS-1 cell |
- |
657744 |
1.14.19.1 | stearoyl-CoA 9-desaturase |
INS-1 cell |
- |
713716 |
1.3.1.24 | biliverdin reductase |
INS-1 cell |
- |
740267 |
2.2.1.1 | transketolase |
INS-1 cell |
insulinoma cell line |
695145 |
2.2.1.1 | transketolase |
INS-1 cell |
insulinoma cell line. Proliferation of cells is not inhibited by transketolase inhibitor benfotiamine |
695145 |
2.3.1.16 | acetyl-CoA C-acyltransferase |
INS-1 cell |
- |
705007 |
2.3.1.24 | sphingosine N-acyltransferase |
INS-1 cell |
- |
752703 |
2.3.3.8 | ATP citrate synthase |
INS-1 cell |
ATP citrate lyase-deficient INS-1 cells, which are unable to convert citrate into cytosolic acetyl-CoA, insulin release by 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid is decreased and adding beta-hydroxybutyrate or alpha-ketoisocaproate, which increases mitochondrial acetoacetate, normalizes 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid-induced insulin release |
685373 |
2.7.1.1 | hexokinase |
INS-1 cell |
- |
703385 |
2.7.8.27 | sphingomyelin synthase |
INS-1 cell |
- |
723537 |
3.1.1.23 | acylglycerol lipase |
INS-1 cell |
- |
-, 751941 |
3.1.3.46 | fructose-2,6-bisphosphate 2-phosphatase |
INS-1 cell |
- |
-, 678087 |
3.1.4.11 | phosphoinositide phospholipase C |
INS-1 cell |
- |
669220 |
3.4.22.1 | cathepsin B |
INS-1 cell |
- |
734235 |
3.5.1.23 | ceramidase |
INS-1 cell |
- |
695405, 752416 |
3.6.5.2 | small monomeric GTPase |
INS-1 cell |
- |
698766 |
6.2.1.4 | succinate-CoA ligase (GDP-forming) |
INS-1 cell |
two distinct ATP-specific and GTP-specific succinyl-CoA synthetases |
650949 |
6.2.1.5 | succinate-CoA ligase (ADP-forming) |
INS-1 cell |
two distinct ATP-specific and GTP-specific succinyl-CoA synthetases |
650949 |
6.4.1.1 | pyruvate carboxylase |
INS-1 cell |
- |
674615 |