EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.205 | IMP dehydrogenase |
T-lymphocyte |
- |
667976, 668295, 669800 |
1.13.11.31 | arachidonate 12-lipoxygenase |
T-lymphocyte |
- |
-, 742978 |
1.13.11.34 | arachidonate 5-lipoxygenase |
T-lymphocyte |
- |
686278, 742001, 743614 |
1.13.11.34 | arachidonate 5-lipoxygenase |
T-lymphocyte |
peripheral cells, including CD4, CD8, CD45RO, CD45RA, T helper type 2, T-cell receptor-alphabeta and -gammadelta expressing cells |
687058 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
T-lymphocyte |
- |
742699, 743296 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
T-lymphocyte |
- |
700937 |
1.14.18.B1 | 5,6-dihydroxyindole-2-carboxylic acid oxidase |
T-lymphocyte |
CD4+ cells, expression analysis of enzyme in cells from healthy persons and systemic lupus erythematosus patients: significantly decreased H3K27me3 levels and increased JMJD3 binding are detected within the ITGAL (CD11a) promoter locus in SLE CD4+ T cells compared with those in healthy CD4+ T cells |
745948 |
1.14.99.29 | deoxyhypusine monooxygenase |
T-lymphocyte |
- |
438287 |
1.3.5.1 | succinate dehydrogenase |
T-lymphocyte |
- |
689710 |
1.8.1.9 | thioredoxin-disulfide reductase |
T-lymphocyte |
development and differentiation of the cells from transgenic mice lacking Txnrd2 expression is not significantly impaired |
685444 |
1.8.4.11 | peptide-methionine (S)-S-oxide reductase |
T-lymphocyte |
overexpression of MsrA in human T-lymphocyte cells protects them against oxidative stress |
658212 |
2.1.1.355 | [histone H3]-lysine9 N-trimethyltransferase |
T-lymphocyte |
- |
704942 |
2.1.1.37 | DNA (cytosine-5-)-methyltransferase |
T-lymphocyte |
CD4+, ranscript levels of DNA methyltransferases DNMT1, DNMT3A and DNMT3B in CD4+ T cells from patients with systemic lupus erythematosus, an autoimmune disease with CD4+ T cells with hypomethylated DNA. It is possible that patients are reacting indirectly to an underlying DNA hypomethylation status by increasing the mRNA levels of DNA methyltransferases when the disease is definitely active, overview |
703987 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
T-lymphocyte |
- |
672939 |
2.3.1.15 | glycerol-3-phosphate 1-O-acyltransferase |
T-lymphocyte |
- |
757868 |
2.3.1.15 | glycerol-3-phosphate 1-O-acyltransferase |
T-lymphocyte |
aging reduces glycerol-3-phosphate acyltransferase activity in activated rat splenic T-lymphocytes |
672318 |
2.3.1.15 | glycerol-3-phosphate 1-O-acyltransferase |
T-lymphocyte |
decreased mtGPAT activity in aged T-lymphocytes |
672373 |
2.3.1.48 | histone acetyltransferase |
T-lymphocyte |
- |
-, 756394 |
2.3.1.51 | 1-acylglycerol-3-phosphate O-acyltransferase |
T-lymphocyte |
- |
487211 |
2.3.1.6 | choline O-acetyltransferase |
T-lymphocyte |
- |
758467 |
2.4.1.102 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
T-lymphocyte |
- |
637982, 759781 |
2.4.1.102 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
T-lymphocyte |
wild-type and transgenic CD4+ T cell lines, induction by cytokines IL-4, and IL-12/STAT4 |
638290 |
2.4.1.146 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase |
T-lymphocyte |
- |
638299, 638301 |
2.4.1.150 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase |
T-lymphocyte |
C2GnT is highly expressed in activated T lymphocytes |
638564 |
2.4.1.214 | glycoprotein 3-alpha-L-fucosyltransferase |
T-lymphocyte |
- |
660887, 662566 |
2.4.1.222 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
T-lymphocyte |
expression levels of three Fringe homologues in naive CD4+T cells in asthmatic rats, overview. Radical Fringe (Rfng) is highly expressed, whereas both Lunatic Fringe (Lfng) and Manic Fringe (Mfng) are expressed at low levels |
723591 |
2.4.1.92 | (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase |
T-lymphocyte |
- |
702508 |
2.4.2.31 | NAD+-protein-arginine ADP-ribosyltransferase |
T-lymphocyte |
- |
638111 |
2.4.2.31 | NAD+-protein-arginine ADP-ribosyltransferase |
T-lymphocyte |
ART2 is a T-cell-specific transferase |
675027 |
2.4.2.31 | NAD+-protein-arginine ADP-ribosyltransferase |
T-lymphocyte |
splenic lymphocyte subpopulations, ART2 is a T-cell-specific transferase, expression of CD38 and ART2 is inversely correlated on murine lymphocytes |
669719 |
2.4.2.31 | NAD+-protein-arginine ADP-ribosyltransferase |
T-lymphocyte |
surface of mature T-lymphocytes |
638111 |
2.4.2.8 | hypoxanthine phosphoribosyltransferase |
T-lymphocyte |
- |
673370 |
2.4.3.2 | beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase |
T-lymphocyte |
CD4, absent in native cells, rapidly up-regulated upon activation |
637747 |
2.4.3.7 | alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase |
T-lymphocyte |
- |
637982 |
2.5.1.6 | methionine adenosyltransferase |
T-lymphocyte |
T helper CD4+ lymphocyte |
681558 |
2.7.1.107 | diacylglycerol kinase (ATP) |
T-lymphocyte |
- |
640357, 640378, 661459, 672450, 673918, 675992, 760532 |
2.7.1.107 | diacylglycerol kinase (ATP) |
T-lymphocyte |
DGK-I |
640375 |
2.7.1.107 | diacylglycerol kinase (ATP) |
T-lymphocyte |
DGK-Ialpha |
640378 |
2.7.1.107 | diacylglycerol kinase (ATP) |
T-lymphocyte |
particularly enriched in peripheral T lymphocytes |
701582 |
2.7.1.127 | inositol-trisphosphate 3-kinase |
T-lymphocyte |
- |
737400 |
2.7.1.137 | phosphatidylinositol 3-kinase |
T-lymphocyte |
- |
707454, 760521 |
2.7.1.137 | phosphatidylinositol 3-kinase |
T-lymphocyte |
T cell line CTLL-2 |
640889 |
2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase |
T-lymphocyte |
- |
-, 739405 |
2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase |
T-lymphocyte |
CD4+ |
709412 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
T-lymphocyte |
- |
641788 |
2.7.1.68 | 1-phosphatidylinositol-4-phosphate 5-kinase |
T-lymphocyte |
- |
738787, 738790, 738794 |
2.7.1.74 | deoxycytidine kinase |
T-lymphocyte |
- |
723637 |
2.7.1.94 | acylglycerol kinase |
T-lymphocyte |
- |
760837 |
2.7.10.1 | receptor protein-tyrosine kinase |
T-lymphocyte |
exclusively expressed in T lymphocytes |
490555 |
2.7.10.2 | non-specific protein-tyrosine kinase |
T-lymphocyte |
- |
490585, 490669, 661273, 661487 |
2.7.10.2 | non-specific protein-tyrosine kinase |
T-lymphocyte |
primary, CD4+ and CD3+ lymphocytes |
675624 |
2.7.11.1 | non-specific serine/threonine protein kinase |
T-lymphocyte |
- |
491646 |
2.7.11.10 | IkappaB kinase |
T-lymphocyte |
- |
662568 |
2.7.11.11 | cAMP-dependent protein kinase |
T-lymphocyte |
- |
661688 |
2.7.11.13 | protein kinase C |
T-lymphocyte |
- |
660959, 662293, 662928 |
2.7.11.13 | protein kinase C |
T-lymphocyte |
peripheral blood CD8+ T cell |
673958 |
2.7.11.15 | beta-adrenergic-receptor kinase |
T-lymphocyte |
- |
661455 |
2.7.11.16 | G-protein-coupled receptor kinase |
T-lymphocyte |
- |
661455 |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
T-lymphocyte |
CaMKIV |
664537 |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
T-lymphocyte |
high expression of CaM-KIV |
664865 |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
T-lymphocyte |
primary |
664750 |
2.7.11.18 | myosin-light-chain kinase |
T-lymphocyte |
- |
675212, 762426 |
2.7.11.2 | [pyruvate dehydrogenase (acetyl-transferring)] kinase |
T-lymphocyte |
- |
660642 |
2.7.11.20 | elongation factor 2 kinase |
T-lymphocyte |
at the level of elongation |
664567 |
2.7.11.24 | mitogen-activated protein kinase |
T-lymphocyte |
- |
491742 |
2.7.7.31 | DNA nucleotidylexotransferase |
T-lymphocyte |
exclusively express hTdTS and hTdTl2 |
662574 |
2.7.7.49 | RNA-directed DNA polymerase |
T-lymphocyte |
- |
692248 |
2.7.7.84 | 2'-5' oligoadenylate synthase |
T-lymphocyte |
no appreciable difference in 2',5'-oligoadenylate synthetase activity is found between T-cells and non-T-cells from cutaneous T-cell lymphomas, increased activity of 2'5'-oligoadenylate synthetase in PBMC from cutaneous T-cell lymphomas forming tetramer, pentamer, and hexamer products |
721572 |
2.7.8.27 | sphingomyelin synthase |
T-lymphocyte |
- |
692624 |
2.8.2.30 | [heparan sulfate]-glucosamine 3-sulfotransferase 3 |
T-lymphocyte |
of peripheral blood, expresssion of 3-OST-3B isoform |
674849 |
2.8.2.8 | [heparan sulfate]-glucosamine N-sulfotransferase |
T-lymphocyte |
CD4+ cells, high expression level of isozyme NDST2. NDST1 is barely detected in naive T-lymphocytes by comparison with memory and activated CD4 T cells, whereas no notable variation in the expression of NDST2 can be distinguished between T cell subsets |
704666 |
3.1.1.4 | phospholipase A2 |
T-lymphocyte |
- |
681856 |
3.1.1.53 | sialate O-acetylesterase |
T-lymphocyte |
- |
715136 |
3.1.1.77 | acyloxyacyl hydrolase |
T-lymphocyte |
interleukin 17-secreting CD4+ helper T cells |
730832 |
3.1.3.16 | protein-serine/threonine phosphatase |
T-lymphocyte |
- |
709112, 709678 |
3.1.3.4 | phosphatidate phosphatase |
T-lymphocyte |
specific expression of DPPL2 |
679998 |
3.1.3.48 | protein-tyrosine-phosphatase |
T-lymphocyte |
- |
678831, 707476, 707865, 708290 |
3.1.3.48 | protein-tyrosine-phosphatase |
T-lymphocyte |
PTPH1 |
709385 |
3.1.3.48 | protein-tyrosine-phosphatase |
T-lymphocyte |
TCPTP |
707688 |
3.1.3.5 | 5'-nucleotidase |
T-lymphocyte |
- |
691839 |
3.1.3.5 | 5'-nucleotidase |
T-lymphocyte |
CD73 is a lymphocyte surface antigen |
716355 |
3.1.3.67 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase |
T-lymphocyte |
- |
694494 |
3.1.3.78 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase |
T-lymphocyte |
- |
715020 |
3.1.4.12 | sphingomyelin phosphodiesterase |
T-lymphocyte |
- |
679144, 716445 |
3.1.4.4 | phospholipase D |
T-lymphocyte |
peripheral |
664608 |
3.1.4.4 | phospholipase D |
T-lymphocyte |
whereas PLD2 is expressed at the plasma membranes of lymphocytes, PLD1 is expressed on intracellular vesicles. PLD1 resides on the same vesicles as Rap1, is delivered along with Rap1 to the plasma membranes of stimulated T cells, and is required for Rap1 activation and T-cell adhesion |
709935 |
3.2.1.166 | heparanase |
T-lymphocyte |
activated |
732436 |
3.2.1.166 | heparanase |
T-lymphocyte |
heparanase occupies regulatory regions of active genes in T cells |
732954 |
3.2.1.18 | exo-alpha-sialidase |
T-lymphocyte |
- |
656030 |
3.2.1.18 | exo-alpha-sialidase |
T-lymphocyte |
only lysosomal Neu1 and plasma membrane-associated Neu3 are detected in freshly isolated and activated human T lymphocytes. Activation of lymphocytes by exposure to anti-CD3 and anti-CD28 IgG results in a ninefold increase in Neu1-specific activity after growth of cells in culture for 5 days. The increase in Neu1 enzyme activity correlates with increased synthesis of Neu1-specific mRNA. Neu1 is present on the surface of freshly isolated and activated CD4 and CD8 T lymphocytes. Cell surface Neu1 is tightly associated with a subunit of protective protein/cathepsin A. Sialidase activity in activated T lymphocytes contributes to the hyposialylation of specific cell surface glycoconjugates and to the production of IFN-gamma |
681254 |
3.2.1.18 | exo-alpha-sialidase |
T-lymphocyte |
only lysosomal Neu1 and plasma membrane-associated Neu3 are detected in freshly isolated and activated human T lymphocytes. Activity of Neu3 changes minimally in activated lymphocytes. Sialidase activity in activated T lymphocytes contributes to the hyposialylation of specific cell surface glycoconjugates and to the production of IFN-gamma |
681254 |
3.2.1.22 | alpha-galactosidase |
T-lymphocyte |
- |
700602 |
3.2.2.27 | uracil-DNA glycosylase |
T-lymphocyte |
low expression level of UNG2 |
709111 |
3.3.2.6 | leukotriene-A4 hydrolase |
T-lymphocyte |
- |
753500 |
3.4.11.2 | membrane alanyl aminopeptidase |
T-lymphocyte |
- |
663842, 664688 |
3.4.11.2 | membrane alanyl aminopeptidase |
T-lymphocyte |
activated |
663607, 665112 |
3.4.11.4 | tripeptide aminopeptidase |
T-lymphocyte |
- |
682590 |
3.4.11.6 | aminopeptidase B |
T-lymphocyte |
- |
665109, 666799 |
3.4.13.18 | cytosol nonspecific dipeptidase |
T-lymphocyte |
- |
137188 |
3.4.14.1 | dipeptidyl-peptidase I |
T-lymphocyte |
cytotoxic |
664627 |