EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
colorectal cancer cell |
- |
697102 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
colorectal cancer cell |
the enzyme expression is down-regulated |
669380 |
1.1.1.153 | sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) |
colorectal cancer cell |
- |
761589 |
1.1.1.40 | malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) |
colorectal cancer cell |
- |
761332 |
1.1.1.428 | 4-methylthio 2-oxobutanoate reductase (NADH) |
colorectal cancer cell |
- |
764279 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
colorectal cancer cell |
- |
656644 |
1.13.11.33 | arachidonate 15-lipoxygenase |
colorectal cancer cell |
HCT-116 |
675909 |
1.13.11.63 | beta-carotene 15,15'-dioxygenase |
colorectal cancer cell |
- |
726652 |
1.14.11.66 | [histone H3]-trimethyl-L-lysine9 demethylase |
colorectal cancer cell |
- |
756531 |
1.14.19.1 | stearoyl-CoA 9-desaturase |
colorectal cancer cell |
- |
746444 |
1.14.99.1 | prostaglandin-endoperoxide synthase |
colorectal cancer cell |
- |
716434 |
1.14.99.66 | [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase |
colorectal cancer cell |
- |
711769 |
1.3.1.1 | dihydropyrimidine dehydrogenase (NAD+) |
colorectal cancer cell |
- |
689367, 689372 |
1.3.8.6 | glutaryl-CoA dehydrogenase (ETF) |
colorectal cancer cell |
overexpression of GCDH |
672889 |
1.5.1.2 | pyrroline-5-carboxylate reductase |
colorectal cancer cell |
- |
762952 |
1.5.1.20 | methylenetetrahydrofolate reductase [NAD(P)H] |
colorectal cancer cell |
- |
690199 |
1.5.99.B2 | proline dehydrogenase (acceptor) |
colorectal cancer cell |
- |
675953 |
2.1.1.1 | nicotinamide N-methyltransferase |
colorectal cancer cell |
- |
733214 |
2.1.1.244 | protein N-terminal methyltransferase |
colorectal cancer cell |
- |
758296 |
2.1.1.299 | protein N-terminal monomethyltransferase |
colorectal cancer cell |
- |
758296 |
2.1.1.346 | U6 snRNA m6A methyltransferase |
colorectal cancer cell |
- |
745965 |
2.1.1.360 | [histone H3]-lysine79 N-trimethyltransferase |
colorectal cancer cell |
- |
753305 |
2.1.1.45 | thymidylate synthase |
colorectal cancer cell |
- |
694482 |
2.1.1.45 | thymidylate synthase |
colorectal cancer cell |
advanced colorectal cancer |
691589 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
colorectal cancer cell |
- |
703539, 704064, 705829, 734793, 757010 |
2.3.1.257 | N-terminal L-serine Nalpha-acetyltransferase NatD |
colorectal cancer cell |
- |
735456 |
2.3.1.257 | N-terminal L-serine Nalpha-acetyltransferase NatD |
colorectal cancer cell |
CRC, NAA40 protein and mRNA levels are commonly increased in CRC primary tissues compared to non-malignant specimens. Quantitative real-time PCR enzyme expression analysis in colorectal cancer cells |
756385 |
2.3.1.45 | N-acetylneuraminate 7-O(or 9-O)-acetyltransferase |
colorectal cancer cell |
- |
677235 |
2.3.1.45 | N-acetylneuraminate 7-O(or 9-O)-acetyltransferase |
colorectal cancer cell |
the relative level of O-acetylated sialic acids and of enzyme activity is decreased in the mucosa from colorectal carcinoma patients compared to the level healthy colon individuals |
651174 |
2.3.1.48 | histone acetyltransferase |
colorectal cancer cell |
- |
756850 |
2.3.1.57 | diamine N-acetyltransferase |
colorectal cancer cell |
- |
757889 |
2.3.1.97 | glycylpeptide N-tetradecanoyltransferase |
colorectal cancer cell |
overexpression of NMT2 in colorectal cancer tissues |
674064 |
2.3.2.5 | glutaminyl-peptide cyclotransferase |
colorectal cancer cell |
- |
759839 |
2.4.1.102 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
colorectal cancer cell |
GCNT3 gene expression is downregulated in colorectal cancer (CRC) samples in comparison to non-pathological colon tissue |
760171 |
2.4.1.150 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase |
colorectal cancer cell |
GCNT3 gene expression is downregulated in colorectal cancer (CRC) samples in comparison to non-pathological colon tissue |
760171 |
2.4.1.68 | glycoprotein 6-alpha-L-fucosyltransferase |
colorectal cancer cell |
- |
721935 |
2.4.1.68 | glycoprotein 6-alpha-L-fucosyltransferase |
colorectal cancer cell |
a significant increase in the alpha(1,6)FT expression in colorectal tumour tissues as compared to healthy and transitional tissues, inflammatory lesions and adenomas is observed |
692664 |
2.4.1.90 | N-acetyllactosamine synthase |
colorectal cancer cell |
- |
755974 |
2.4.2.10 | orotate phosphoribosyltransferase |
colorectal cancer cell |
- |
677169 |
2.4.2.10 | orotate phosphoribosyltransferase |
colorectal cancer cell |
Dukes B and C colorectal carcinoma cells |
685814 |
2.4.2.12 | nicotinamide phosphoribosyltransferase |
colorectal cancer cell |
- |
735872 |
2.4.2.2 | pyrimidine-nucleoside phosphorylase |
colorectal cancer cell |
PyNPase level quantified by sandwich ELISA using monoclonal anti-human thimidine phosphorylase antibodies 104B and 232-2, no association between PyNPase level and recurrence, disease-free survival at year 2.2 better with low PyNPase levels and high PyNPase-to-dihydropyrimidine dihydrogenase ratio |
692551 |
2.4.2.29 | tRNA-guanosine34 preQ1 transglycosylase |
colorectal cancer cell |
the expression level of the 60000 Da subunit is elevated in four of five colon cancer cell lines and 83% of colon cancer tissue compared with normal tissue |
658379 |
2.4.2.31 | NAD+-protein-arginine ADP-ribosyltransferase |
colorectal cancer cell |
- |
736267, 759354 |
2.4.2.4 | thymidine phosphorylase |
colorectal cancer cell |
- |
660558, 684229, 684459, 759291 |
2.4.2.4 | thymidine phosphorylase |
colorectal cancer cell |
enzyme activity is higher in cancer tiddue than in adjacent normal tissue |
659750 |
2.4.2.64 | tRNA-guanosine34 queuine transglycosylase |
colorectal cancer cell |
the expression level of the 60000 Da subunit is elevated in four of five colon cancer cell lines and 83% of colon cancer tissue compared with normal tissue |
758989 |
2.4.2.8 | hypoxanthine phosphoribosyltransferase |
colorectal cancer cell |
- |
759769 |
2.4.3.1 | beta-galactoside alpha-(2,6)-sialyltransferase |
colorectal cancer cell |
- |
758990, 759313 |
2.5.1.22 | spermine synthase |
colorectal cancer cell |
- |
759826 |
2.7.1.107 | diacylglycerol kinase (ATP) |
colorectal cancer cell |
- |
761306 |
2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase |
colorectal cancer cell |
- |
707974 |
2.7.1.20 | adenosine kinase |
colorectal cancer cell |
adenosine kinase gene expression is significantly higher in cancer than in normal-appearing tissue |
689272 |
2.7.1.32 | choline kinase |
colorectal cancer cell |
- |
760183 |
2.7.1.40 | pyruvate kinase |
colorectal cancer cell |
- |
673438 |
2.7.10.1 | receptor protein-tyrosine kinase |
colorectal cancer cell |
overexpression of VEGFR1-3 |
661551 |
2.7.10.2 | non-specific protein-tyrosine kinase |
colorectal cancer cell |
- |
703579 |
2.7.11.1 | non-specific serine/threonine protein kinase |
colorectal cancer cell |
- |
737936, 739739, 760350 |
2.7.11.10 | IkappaB kinase |
colorectal cancer cell |
- |
762079 |
2.7.11.19 | phosphorylase kinase |
colorectal cancer cell |
- |
761576 |
2.7.11.20 | elongation factor 2 kinase |
colorectal cancer cell |
- |
760810 |
2.7.12.2 | mitogen-activated protein kinase kinase |
colorectal cancer cell |
- |
740944 |
2.7.2.3 | phosphoglycerate kinase |
colorectal cancer cell |
moderate PGK1 expression |
682792 |
2.7.4.21 | inositol-hexakisphosphate 5-kinase |
colorectal cancer cell |
- |
723635 |
2.7.7.1 | nicotinamide-nucleotide adenylyltransferase |
colorectal cancer cell |
exhibits low levels of NMNAT2 |
737971 |
2.7.7.49 | RNA-directed DNA polymerase |
colorectal cancer cell |
- |
694207 |
2.8.2.33 | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase |
colorectal cancer cell |
samples from 40 patients, enzyme expression analysis by real-time RT-PCR and in situ hybridization in formalin-fixed and paraffin-embedded tissue sections, comparison to healthy tissue |
671169 |
3.1.1.1 | carboxylesterase |
colorectal cancer cell |
enzyme overexpression |
729359 |
3.1.1.1 | carboxylesterase |
colorectal cancer cell |
the expression of carboxylesterase 2 in colorectal cancer tissue is downregulated following progression of disease |
691591 |
3.1.1.118 | phospholipid sn-1 acylhydrolase |
colorectal cancer cell |
- |
761626 |
3.1.3.3 | phosphoserine phosphatase |
colorectal cancer cell |
- |
749588, 749807 |
3.1.3.48 | protein-tyrosine-phosphatase |
colorectal cancer cell |
- |
710432 |
3.1.3.67 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase |
colorectal cancer cell |
decreased enzyme in colorectal cancer |
716688 |
3.1.3.86 | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase |
colorectal cancer cell |
- |
751770 |
3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase |
colorectal cancer cell |
- |
750402 |
3.2.2.29 | thymine-DNA glycosylase |
colorectal cancer cell |
- |
732173 |
3.2.2.5 | NAD+ glycohydrolase |
colorectal cancer cell |
enzyme level and ADP-ribosylation is significantly higher in patients and are correlated with tumour stage |
732965 |
3.3.2.6 | leukotriene-A4 hydrolase |
colorectal cancer cell |
- |
-, 707984, 752495, 753405 |
3.3.2.6 | leukotriene-A4 hydrolase |
colorectal cancer cell |
LTA4H and BLT1 are overexpressed in colitis and correlate with colon adenocarcinoma, phenotypes, overview |
753405 |
3.3.2.6 | leukotriene-A4 hydrolase |
colorectal cancer cell |
LTA4H shows increased expression along with increased LTB4 in an azoxymethane-induced colorectal cancer (CRC) mouse model |
752495 |
3.4.13.19 | membrane dipeptidase |
colorectal cancer cell |
- |
678655 |
3.4.17.21 | Glutamate carboxypeptidase II |
colorectal cancer cell |
primary cancer |
708666 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
colorectal cancer cell |
lymph node metastasis, increased expression |
709233 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
colorectal cancer cell |
present in cancerous cells originating from tissues that do not normally express UCH-L1, including pancreatic cancer, colorectal cancer and invasive breast cancer |
752715 |
3.4.19.9 | folate gamma-glutamyl hydrolase |
colorectal cancer cell |
- |
707955 |
3.4.19.9 | folate gamma-glutamyl hydrolase |
colorectal cancer cell |
primary, low enzyme expression level in cells from the CpG island methylator phenotype, overview |
683310 |
3.4.21.104 | mannan-binding lectin-associated serine protease-2 |
colorectal cancer cell |
- |
684060 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
colorectal cancer cell |
semi-quantitative RT-PCR determination and immunohistochemical analysis |
710599 |
3.4.21.26 | prolyl oligopeptidase |
colorectal cancer cell |
- |
732260 |
3.4.21.35 | tissue kallikrein |
colorectal cancer cell |
- |
732959 |
3.4.21.73 | u-Plasminogen activator |
colorectal cancer cell |
- |
683299, 707901 |
3.4.21.73 | u-Plasminogen activator |
colorectal cancer cell |
differences in uPA and uPAR expression and clinicopathologic features of patients with mismatch repair-proficient colorectal cancer, immunohistochemic tissue analysis, overview |
708669 |
3.4.21.B28 | fibroblast activation protein alpha subunit |
colorectal cancer cell |
higher levels in cancer tissue than normal tissue |
672887 |
3.4.21.B41 | kallikrein 10 |
colorectal cancer cell |
- |
681167 |
3.4.21.B41 | kallikrein 10 |
colorectal cancer cell |
immunohistochemic expression analysis, overview |
732959 |
3.4.21.B6 | prostasin |
colorectal cancer cell |
- |
707869 |
3.4.22.1 | cathepsin B |
colorectal cancer cell |
- |
668469, 696963, 697788, 734676 |
3.4.22.15 | cathepsin L |
colorectal cancer cell |
- |
752853 |
3.4.22.34 | Legumain |
colorectal cancer cell |
high enzyme expression level |
668278 |
3.4.22.34 | Legumain |
colorectal cancer cell |
legumain is overexpressed in the majority of human solid tumours, including breast cancer, colorectal cancer, ovarian cancer, prostate cancer and gastric cancer |
752851 |