EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
osteoblast |
- |
699216 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
osteoblast |
isoform 11betaHSD1 |
741066 |
1.1.1.213 | 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific) |
osteoblast |
fetal |
687639 |
1.1.1.38 | malate dehydrogenase (oxaloacetate-decarboxylating) |
osteoblast |
- |
760840 |
1.1.1.49 | glucose-6-phosphate dehydrogenase (NADP+) |
osteoblast |
- |
711728 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
osteoblast |
- |
741242 |
1.13.11.5 | homogentisate 1,2-dioxygenase |
osteoblast |
- |
725601 |
1.14.11.4 | procollagen-lysine 5-dioxygenase |
osteoblast |
- |
-, 674991, 696018, 725464, 745431 |
1.14.11.4 | procollagen-lysine 5-dioxygenase |
osteoblast |
primary calvarial |
-, 746171 |
1.14.11.53 | mRNA N6-methyladenine demethylase |
osteoblast |
- |
764672 |
1.14.11.7 | procollagen-proline 3-dioxygenase |
osteoblast |
- |
672947 |
1.14.15.18 | calcidiol 1-monooxygenase |
osteoblast |
1-OHase mRNA expression is highest in pre-menopausal women and is increased by all hormones tested. In post-menopausal osteoblasts all hormones except biochainin A and genistein increase 1-OHase mRNA expressions to less extent. In male-derived osteoblasts only dihydrotestosterone and carboxybiochainin A increase 1-OHase mRNA expression |
688682 |
1.14.15.6 | cholesterol monooxygenase (side-chain-cleaving) |
osteoblast |
- |
705739 |
1.14.15.6 | cholesterol monooxygenase (side-chain-cleaving) |
osteoblast |
expresses an approximately 32-kDa truncated isoform of CYP11A1, expression of an approximately 32-kDa truncated isoform of CYP11A1 |
705739 |
1.21.99.4 | thyroxine 5'-deiodinase |
osteoblast |
the enzyme is restricted to mature primary osteoblasts |
716774 |
1.4.3.13 | protein-lysine 6-oxidase |
osteoblast |
- |
684322 |
1.4.3.13 | protein-lysine 6-oxidase |
osteoblast |
expression of isozymes during osteoblast differentiation is highly regulated due to their distinct roles in collagen matrix stabilization and subsequent mineralization |
657782 |
1.6.2.4 | NADPH-hemoprotein reductase |
osteoblast |
primary from mouse calvariae |
724179 |
2.1.1.204 | tRNA (cytosine38-C5)-methyltransferase |
osteoblast |
- |
-, 736018 |
2.1.1.348 | mRNA m6A methyltransferase |
osteoblast |
- |
755980 |
2.3.1.255 | N-terminal amino-acid Nalpha-acetyltransferase NatA |
osteoblast |
- |
756675 |
2.3.1.255 | N-terminal amino-acid Nalpha-acetyltransferase NatA |
osteoblast |
located around new bone surfaces |
756332 |
2.3.1.48 | histone acetyltransferase |
osteoblast |
- |
702497 |
2.3.1.57 | diamine N-acetyltransferase |
osteoblast |
- |
-, 737285 |
2.4.1.132 | GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase |
osteoblast |
- |
-, 736467 |
2.4.1.41 | polypeptide N-acetylgalactosaminyltransferase |
osteoblast |
- |
704654 |
2.4.3.9 | lactosylceramide alpha-2,3-sialyltransferase |
osteoblast |
- |
736270 |
2.5.1.29 | geranylgeranyl diphosphate synthase |
osteoblast |
- |
673666, 722863 |
2.7.1.137 | phosphatidylinositol 3-kinase |
osteoblast |
inhibition of PI3-kinase induces apoptotic cell death, which is mediated by inactivation of Akt pathway in rat osteoblasts |
685497 |
2.7.1.32 | choline kinase |
osteoblast |
- |
737751 |
2.7.1.36 | mevalonate kinase |
osteoblast |
- |
708647 |
2.7.10.1 | receptor protein-tyrosine kinase |
osteoblast |
- |
673570 |
2.7.10.2 | non-specific protein-tyrosine kinase |
osteoblast |
PYK2 |
673223 |
2.7.11.1 | non-specific serine/threonine protein kinase |
osteoblast |
- |
662407 |
2.7.11.10 | IkappaB kinase |
osteoblast |
- |
662547 |
2.7.11.12 | cGMP-dependent protein kinase |
osteoblast |
- |
662407, 761605 |
2.7.11.12 | cGMP-dependent protein kinase |
osteoblast |
primary |
676003, 722412 |
2.7.11.24 | mitogen-activated protein kinase |
osteoblast |
- |
680636 |
2.7.11.26 | tau-protein kinase |
osteoblast |
- |
705455 |
2.7.11.31 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase |
osteoblast |
- |
-, 703618 |
2.7.4.21 | inositol-hexakisphosphate 5-kinase |
osteoblast |
- |
738740 |
2.8.2.4 | estrone sulfotransferase |
osteoblast |
- |
693892 |
3.1.3.1 | alkaline phosphatase |
osteoblast |
- |
650752, 652666 |
3.1.3.1 | alkaline phosphatase |
osteoblast |
cell surface |
650793 |
3.1.3.2 | acid phosphatase |
osteoblast |
fetal osteoblastic cells hFOB1.19: TRAP activity and the reduced glutathione-dependent microenvironment are modulated during osteoblastic differentiation. During this phase, TRAP activity, as well as alkaline phosphatase and glutathione increases progressively up to the 21st day, decreasing thereafter |
693701 |
3.1.3.48 | protein-tyrosine-phosphatase |
osteoblast |
primary osteoblast |
650086 |
3.1.3.75 | phosphoethanolamine/phosphocholine phosphatase |
osteoblast |
- |
702017 |
3.1.3.75 | phosphoethanolamine/phosphocholine phosphatase |
osteoblast |
expressed by active alveolar bone osteoblasts and cementoblasts during cellular cementum formation |
751205 |
3.1.4.1 | phosphodiesterase I |
osteoblast |
- |
697243, 709235, 730170 |
3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase |
osteoblast |
cultured, PDE1 |
668213 |
3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase |
osteoblast |
cultured, PDE3 |
668213 |
3.1.4.4 | phospholipase D |
osteoblast |
- |
707551, 709177 |
3.1.4.4 | phospholipase D |
osteoblast |
calvarial osteoblastic cell |
707551 |
3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase |
osteoblast |
cultured, PDE7 |
668213 |
3.2.1.166 | heparanase |
osteoblast |
isolated from trabecular bone specimens of patients with osteoporosis and from healthy subjects |
705306 |
3.4.15.1 | peptidyl-dipeptidase A |
osteoblast |
- |
707920 |
3.4.17.1 | carboxypeptidase A |
osteoblast |
- |
668122 |
3.4.17.12 | carboxypeptidase M |
osteoblast |
- |
697395 |
3.4.18.1 | cathepsin X |
osteoblast |
- |
708633 |
3.4.21.B12 | prostase |
osteoblast |
of prostate cancer bone metastases |
689848 |
3.4.21.B25 | PACE4 proprotein convertase |
osteoblast |
- |
732215 |
3.4.21.B26 | proprotein convertase 5 |
osteoblast |
primary culture |
753112 |
3.4.22.34 | Legumain |
osteoblast |
- |
651949 |
3.4.22.38 | cathepsin K |
osteoblast |
- |
697066, 700688 |
3.4.22.38 | cathepsin K |
osteoblast |
osteoblast-like culture. Osteoblastic cathepsin K may contribute to collagenous matrix maintenance and recycling of improperly processed collagen I |
668097 |
3.4.22.47 | gingipain K |
osteoblast |
- |
-, 696111 |
3.4.22.62 | caspase-9 |
osteoblast |
incubated with 0.5-30 mg/l of sodium fluoride (NaF) |
695934 |
3.4.24.11 | neprilysin |
osteoblast |
osteoblastic cell line PyMS |
670864 |
3.4.24.19 | procollagen C-endopeptidase |
osteoblast |
- |
668838 |
3.4.24.34 | neutrophil collagenase |
osteoblast |
expression of MMP-8 does not change significantly in ovariectomized rat |
-, 669911 |
3.4.24.35 | gelatinase B |
osteoblast |
- |
700527 |
3.4.24.65 | macrophage elastase |
osteoblast |
- |
754996 |
3.4.24.79 | pappalysin-1 |
osteoblast |
- |
638937, 638938, 683711 |
3.4.24.79 | pappalysin-1 |
osteoblast |
expression analysis, overview |
683411 |
3.4.24.86 | ADAM 17 endopeptidase |
osteoblast |
- |
719165 |
3.4.24.B10 | ADAM12 endopeptidase |
osteoblast |
- |
669565 |
3.4.24.B15 | PHEX peptidase |
osteoblast |
- |
649294, 681076, 718551 |
3.4.24.B15 | PHEX peptidase |
osteoblast |
cell culture |
649294 |
3.4.24.B15 | PHEX peptidase |
osteoblast |
fully differentiated, from calvaria of newborn mice |
-, 668096 |
3.4.24.B15 | PHEX peptidase |
osteoblast |
MC3T3-E1 clonal osteoblast, not in immature MC3T3-E1 preosteoblasts |
693297 |
3.4.24.B15 | PHEX peptidase |
osteoblast |
osteosarcoma-derived MG-63 osteoblast |
693297 |
3.4.24.B15 | PHEX peptidase |
osteoblast |
PHEX colocalizes with heparan sulfate at the cell surface of osteoblasts |
692642 |
3.4.24.B4 | matrix metalloproteinase-13 |
osteoblast |
- |
650906, 677406, 711853, 712007, 712498 |
3.4.24.B4 | matrix metalloproteinase-13 |
osteoblast |
enzyme expression during bone development |
652802 |
3.4.24.B4 | matrix metalloproteinase-13 |
osteoblast |
primary |
712382 |
3.4.24.B9 | ADAM9 endopeptidase |
osteoblast |
recombinant enzyme promotes a fivefold increase in interleukin IL-6, but not IL-1beta mRNA. Enzyme binds directly to alphabeta5 integrin |
668073 |
3.6.1.9 | nucleotide diphosphatase |
osteoblast |
enzyme knockout osteoblast cell |
667143 |
3.6.4.13 | RNA helicase |
osteoblast |
- |
756284 |
3.6.5.2 | small monomeric GTPase |
osteoblast |
- |
699116 |
3.6.5.2 | small monomeric GTPase |
osteoblast |
from femur marrow |
684452 |
3.6.5.2 | small monomeric GTPase |
osteoblast |
Rho-mediated signaling in osteoblasts seems to introduce major biases to bone resorption |
684840 |
4.1.1.90 | peptidyl-glutamate 4-carboxylase |
osteoblast |
- |
746967 |
4.6.1.14 | glycosylphosphatidylinositol diacylglycerol-lyase |
osteoblast |
- |
715721 |
5.3.99.2 | Prostaglandin-D synthase |
osteoblast |
- |
715626 |
5.6.2.4 | DNA 3'-5' helicase |
osteoblast |
- |
758107 |
6.1.1.1 | tyrosine-tRNA ligase |
osteoblast |
- |
705526 |
6.1.1.22 | asparagine-tRNA ligase |
osteoblast |
- |
702933 |
6.3.1.2 | glutamine synthetase |
osteoblast |
- |
691521 |
6.3.1.2 | glutamine synthetase |
osteoblast |
primary derived from bone marrow |
691521 |
7.6.2.1 | P-type phospholipid transporter |
osteoblast |
- |
668247 |