EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.188 | prostaglandin-F synthase |
renal cell carcinoma cell |
the enzyme is associated with the cyclooxygenase-II, COX-II |
667423 |
1.1.5.13 | (S)-2-hydroxyglutarate dehydrogenase |
renal cell carcinoma cell |
- |
753297 |
1.14.11.66 | [histone H3]-trimethyl-L-lysine9 demethylase |
renal cell carcinoma cell |
- |
756531 |
1.14.15.16 | vitamin D3 24-hydroxylase |
renal cell carcinoma cell |
- |
724907 |
1.14.15.18 | calcidiol 1-monooxygenase |
renal cell carcinoma cell |
RT-PCR and immunohistochemic expression analysis |
712553 |
1.14.18.B1 | 5,6-dihydroxyindole-2-carboxylic acid oxidase |
renal cell carcinoma cell |
- |
745947 |
1.21.99.4 | thyroxine 5'-deiodinase |
renal cell carcinoma cell |
ccRCC |
701298 |
1.3.1.24 | biliverdin reductase |
renal cell carcinoma cell |
increased activity of BVR, but only in the presence of NADH |
676353 |
1.4.3.13 | protein-lysine 6-oxidase |
renal cell carcinoma cell |
- |
687919 |
1.5.1.2 | pyrroline-5-carboxylate reductase |
renal cell carcinoma cell |
- |
713158 |
2.1.1.321 | type III protein arginine methyltransferase |
renal cell carcinoma cell |
overexpression in renal cell carcinoma |
756929 |
2.1.1.359 | [histone H3]-lysine36 N-trimethyltransferase |
renal cell carcinoma cell |
- |
754937 |
2.3.1.135 | phosphatidylcholine-retinol O-acyltransferase |
renal cell carcinoma cell |
metastatic |
658462 |
2.4.1.41 | polypeptide N-acetylgalactosaminyltransferase |
renal cell carcinoma cell |
RCC 7860, expression detected by Western blot |
689866 |
2.4.2.4 | thymidine phosphorylase |
renal cell carcinoma cell |
- |
638468 |
2.4.3.2 | beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase |
renal cell carcinoma cell |
- |
759761 |
2.4.3.2 | beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase |
renal cell carcinoma cell |
a high level of ST3Gal II mRNA was detected in all human RCC cell lines except SMKT-R2 |
745272 |
2.7.1.3 | ketohexokinase |
renal cell carcinoma cell |
represent the most prevalent cancer of the kidney. The mean ketohexokinase activity in the renal cell carcinoma tissue samples is approximately 1.4fold lower than that in their normal kidney tissue. Ketohexokinase activity is approximately 1.5fold lower in pT3 renal cell carcinoma tissue than that in pT1 renal cell carcinoma tissue. The enzyme activity of tumor in histological grade 3 is 1.8fold lower than for grade 1 tumor(reaction mixture activity assay: acid-treated supernatant (100 microl) containing 10 mM MgCl2, 50 mM TrisHCl, pH 7.4, 10 mM ATP, 50 mM N-acetyl-D-glucosamine, 10 mM D[UL-14C]fructose and water, at 37°C). The expression level of ketohexokinase mRNA is reduced two- to eightfold in nearly all the clear cell renal cell carcinoma tissue samples compared with normal kidney, except for one renal cell carcinoma sample. |
682791 |
2.7.11.25 | mitogen-activated protein kinase kinase kinase |
renal cell carcinoma cell |
c-Raf |
682213 |
3.1.4.39 | alkylglycerophosphoethanolamine phosphodiesterase |
renal cell carcinoma cell |
- |
696397 |
3.2.1.113 | mannosyl-oligosaccharide 1,2-alpha-mannosidase |
renal cell carcinoma cell |
- |
751168 |
3.2.1.166 | heparanase |
renal cell carcinoma cell |
- |
714936 |
3.2.1.52 | beta-N-acetylhexosaminidase |
renal cell carcinoma cell |
a similar pattern in activity of isoforms of isoenzymes A and B in normal and cancerous renal tissue is observed |
679259 |
3.3.2.10 | soluble epoxide hydrolase |
renal cell carcinoma cell |
sEH expression in renal malignant neoplasms and surrounding non-neoplastic tissues is significantly decreased |
681501 |
3.4.11.14 | cytosol alanyl aminopeptidase |
renal cell carcinoma cell |
- |
677492 |
3.4.11.21 | aspartyl aminopeptidase |
renal cell carcinoma cell |
- |
677492 |
3.4.17.12 | carboxypeptidase M |
renal cell carcinoma cell |
tumor cells of renal cell carcinoma subtypes lose carboxypeptidase M expression upon dedifferentiation. There is a correlation between low carboxypeptidase M expression and tumor cell type. Carboxypeptidase M staining is intense on phagocytotic tumor-associated macrophages, and enzyme is also detected in the tumor-associated vasculature. Coexistence of carboxypeptidase M and the epidermal growth factor receptor is detected in papillary renal cell carcinoma |
732261 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
renal cell carcinoma cell |
expression analysis of UCHL! in the renal cell carcinoma system, profiling, overview |
710517 |
3.4.21.106 | hepsin |
renal cell carcinoma cell |
- |
675701 |
3.4.21.106 | hepsin |
renal cell carcinoma cell |
hepsin mRNA levels in early stage cancer are similar to that in normal controls but mRNA levels decrease in more advanced cancers. Patients with lower hepsin mRNA levels have poorer survival rate. In contrast, another study reports lower hepsin mRNA expression in early stage cancers, in some cases of advanced cancer overexpression of hepsin mRNA and patients with high hepsin mRNA levels with poorer survival rates |
686903 |
3.4.21.B39 | stratum corneum tryptic enzyme |
renal cell carcinoma cell |
decreased immunohistochemical expression compared to normal cells |
670981 |
3.4.21.B41 | kallikrein 10 |
renal cell carcinoma cell |
decreased expression compared to normal cell |
670981 |
3.4.23.B1 | napsin |
renal cell carcinoma cell |
- |
658356, 711657, 712132, 754263 |
3.4.23.B1 | napsin |
renal cell carcinoma cell |
expression in only one of 29 renal cell carcinomas determined, correlation to loss of napsin A expression in high-grade lung adenocarcinomas |
683839 |
3.4.24.11 | neprilysin |
renal cell carcinoma cell |
- |
709805 |
3.4.24.22 | stromelysin 2 |
renal cell carcinoma cell |
- |
686576 |
3.4.24.23 | matrilysin |
renal cell carcinoma cell |
- |
683362 |
3.4.24.23 | matrilysin |
renal cell carcinoma cell |
higher expression of MMP-7 in RCC subtypes, i.e. chromophobe, renal papillary and oncocytomas, compared to benign epithelial neoplasias, overview |
683563 |
3.5.1.14 | N-acyl-aliphatic-L-amino acid amidohydrolase |
renal cell carcinoma cell |
- |
697141 |
3.5.4.3 | guanine deaminase |
renal cell carcinoma cell |
- |
688301 |
4.1.1.17 | ornithine decarboxylase |
renal cell carcinoma cell |
- |
677508 |
4.2.1.2 | fumarate hydratase |
renal cell carcinoma cell |
all missense mutations of fumarate hydratase associating with MCUL/hereditary leiomyomatosis and renal cell cancer show diminished fumarate hydratase enzymatic |
666096 |
4.2.1.2 | fumarate hydratase |
renal cell carcinoma cell |
loss of fumarate hydratase might be a significant event in the pathogenesis of a subset of nonsyndromic uterine leiomyomas |
665051 |
5.1.99.4 | alpha-methylacyl-CoA racemase |
renal cell carcinoma cell |
type 1 and type 2 papillary, conventional, and chromophobe renal cell carcinoma, oncocytomas, mucinous tubular and spindle tumors, urothelial carcinomas, angiomyolipomas, and Bellini carcinomas, immunohistochemical analysis of enzyme expression, overview |
680089 |
5.3.3.12 | L-dopachrome isomerase |
renal cell carcinoma cell |
- |
727986 |
5.6.2.1 | DNA topoisomerase |
renal cell carcinoma cell |
- |
714760 |
6.1.1.10 | methionine-tRNA ligase |
renal cell carcinoma cell |
RAG |
32 |
6.2.1.1 | acetate-CoA ligase |
renal cell carcinoma cell |
- |
744665 |
6.3.4.3 | formate-tetrahydrofolate ligase |
renal cell carcinoma cell |
- |
765141 |
6.3.5.3 | phosphoribosylformylglycinamidine synthase |
renal cell carcinoma cell |
- |
1664 |