EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.1 | alcohol dehydrogenase |
skin |
- |
691867 |
1.1.1.105 | all-trans-retinol dehydrogenase (NAD+) |
skin |
- |
761505 |
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
skin |
- |
699476 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
skin |
- |
763756 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
skin |
3beta-HSD I |
389395 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
skin |
3betaHSD VI |
389384 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
skin |
in the skin, positive immunoreactivities to isoform Hsd3b6 are only seen in the sebaceous glands |
740997 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
skin |
- |
762406 |
1.1.1.149 | 20alpha-hydroxysteroid dehydrogenase |
skin |
fibroblast |
285997 |
1.1.1.149 | 20alpha-hydroxysteroid dehydrogenase |
skin |
very low expression rate of AKR1C23 |
669908 |
1.1.1.188 | prostaglandin-F synthase |
skin |
- |
740413 |
1.1.1.188 | prostaglandin-F synthase |
skin |
AKR1C3 is overexpressed in the fibrotic area of keloids (scarfs) while relatively weak staining is detected in normal skin |
740414 |
1.1.1.211 | long-chain-3-hydroxyacyl-CoA dehydrogenase |
skin |
- |
686162 |
1.1.1.22 | UDP-glucose 6-dehydrogenase |
skin |
- |
286296 |
1.1.1.278 | 3beta-hydroxy-5alpha-steroid dehydrogenase |
skin |
pubic |
639085 |
1.1.1.300 | NADP-retinol dehydrogenase |
skin |
- |
761045 |
1.1.1.300 | NADP-retinol dehydrogenase |
skin |
and foreskin |
656810 |
1.1.1.34 | hydroxymethylglutaryl-CoA reductase (NADPH) |
skin |
from tail |
-, 687713 |
1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase |
skin |
- |
713515 |
1.1.1.53 | 3alpha(or 20beta)-hydroxysteroid dehydrogenase |
skin |
high expression of subunit A, moderate expression of subunit B |
762606 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
skin |
detectable in sebaceous glands, absent in epidermis, stroma, hair follicles and sweat glands |
656578 |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
skin |
moderate expression |
685803 |
1.1.1.64 | testosterone 17beta-dehydrogenase (NADP+) |
skin |
expression in male, hardly detectable in female |
669905 |
1.11.1.12 | phospholipid-hydroperoxide glutathione peroxidase |
skin |
- |
673845 |
1.11.1.8 | iodide peroxidase |
skin |
- |
712669 |
1.11.1.9 | glutathione peroxidase |
skin |
- |
396635 |
1.13.11.20 | cysteine dioxygenase |
skin |
- |
725864 |
1.13.11.31 | arachidonate 12-lipoxygenase |
skin |
- |
395426, 660410, 702435 |
1.13.11.33 | arachidonate 15-lipoxygenase |
skin |
- |
702435 |
1.13.11.33 | arachidonate 15-lipoxygenase |
skin |
15-LOX-1 and 15-LOX-2 |
706877 |
1.13.11.40 | arachidonate 8-lipoxygenase |
skin |
- |
439398, 439401, 702435 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
skin |
- |
395495, 713591 |
1.13.11.63 | beta-carotene 15,15'-dioxygenase |
skin |
epidermis |
713952 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
skin |
- |
439148, 439149, 439225 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
skin |
embryo |
439148, 439200 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
skin |
fetal |
659280 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
skin |
fetus |
439211, 439225 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
skin |
fetus, adult |
439211 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
skin |
highest enzyme activity |
-, 439200 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
skin |
new born |
439149, 439223 |
1.14.11.4 | procollagen-lysine 5-dioxygenase |
skin |
- |
-, 657744, 675017, 698942, 724792, 745334, 745445, 746171 |
1.14.11.4 | procollagen-lysine 5-dioxygenase |
skin |
expression only of LH2long |
659845 |
1.14.11.4 | procollagen-lysine 5-dioxygenase |
skin |
fetus |
439155 |
1.14.11.4 | procollagen-lysine 5-dioxygenase |
skin |
fibroblasts |
439163 |
1.14.11.4 | procollagen-lysine 5-dioxygenase |
skin |
fibrotic skin from patients with systemic sclerosis |
659266 |
1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase |
skin |
- |
744861 |
1.14.11.65 | [histone H3]-dimethyl-L-lysine9 demethylase |
skin |
high expression level |
744861 |
1.14.11.7 | procollagen-proline 3-dioxygenase |
skin |
- |
712433 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
skin |
n the skin, eNOS is present in the epidermal layer, hair follicles and also in the endothelial cells lining the blood vessels |
701194 |
1.14.13.8 | flavin-containing monooxygenase |
skin |
- |
673313 |
1.14.14.177 | ultra-long-chain fatty acid omega-hydroxylase |
skin |
- |
762269 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
skin |
- |
687555 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
skin |
increased expression on inflammation, particularly in infiltrating cells |
658343 |
1.14.14.29 | 25/26-hydroxycholesterol 7alpha-hydroxylase |
skin |
activity is detected in keratinocytes of the spinous and granula layers, and to lesser extent in the basal layer and basal cell bodies. High activity in hair follicle associated cells |
688678 |
1.14.14.94 | leukotriene-B4 20-monooxygenase |
skin |
- |
701913 |
1.14.14.94 | leukotriene-B4 20-monooxygenase |
skin |
CYP4F2 |
660409 |
1.14.14.94 | leukotriene-B4 20-monooxygenase |
skin |
transcript abundance is highest for Cyp4f13 and 4f16 genes, lowest for Cyp4f14, 4f17, and 4f37, and intermediate for Cyp4f18 and 4f39. Transcripts arising from Cyp4f15 are highly variable, ranging from intermediate to undetectable levels in individual mice. Transcripts arising from Cyp4f40 are present, but levels are too low to measure reliably in most mice |
-, 701913 |
1.14.15.16 | vitamin D3 24-hydroxylase |
skin |
- |
714836 |
1.14.15.18 | calcidiol 1-monooxygenase |
skin |
- |
688675 |
1.14.15.4 | steroid 11beta-monooxygenase |
skin |
- |
686286 |
1.14.16.4 | tryptophan 5-monooxygenase |
skin |
- |
658187, 728061 |
1.14.17.3 | peptidylglycine monooxygenase |
skin |
- |
438569, 438573, 438576, 716946 |
1.14.17.3 | peptidylglycine monooxygenase |
skin |
soluble enzyme with peptidylglycine alpha-hydroxylating activity or peptidylhydroxylglycine N-C lyase activity |
438583, 438584 |
1.14.17.3 | peptidylglycine monooxygenase |
skin |
soluble enzyme with peptidylglycine alpha-hydroxylating activity, AE-I |
438585 |
1.14.17.4 | aminocyclopropanecarboxylate oxidase |
skin |
- |
700917 |
1.14.18.1 | tyrosinase |
skin |
- |
636364, 636385, 636407, 697464, 744671, 746188 |
1.14.18.1 | tyrosinase |
skin |
human fresh skin tissues from volunteers |
684735 |
1.14.18.5 | sphingolipid C4-monooxygenase |
skin |
highest expression in skin |
719485 |
1.14.18.6 | 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase |
skin |
- |
733284 |
1.14.19.1 | stearoyl-CoA 9-desaturase |
skin |
- |
698917, 727982 |
1.14.19.1 | stearoyl-CoA 9-desaturase |
skin |
isoforms SCD-1, SCD-2, and SCD-3 |
695472 |
1.14.19.1 | stearoyl-CoA 9-desaturase |
skin |
mature sebocytes |
746542 |
1.14.19.1 | stearoyl-CoA 9-desaturase |
skin |
sebocytes, SCD3 isoform |
673285 |
1.14.19.3 | acyl-CoA 6-desaturase |
skin |
- |
659649 |
1.14.19.47 | acyl-lipid (9-3)-desaturase |
skin |
DELTA6fad is constitutively expressed |
744748 |
1.14.19.53 | all-trans-retinol 3,4-desaturase |
skin |
- |
745368 |
1.14.99.38 | cholesterol 25-monooxygenase |
skin |
- |
700999 |
1.15.1.1 | superoxide dismutase |
skin |
low expression level |
744746 |
1.17.1.3 | leucoanthocyanidin reductase |
skin |
berry skin, low level of LAR1 expression |
676588 |
1.17.1.3 | leucoanthocyanidin reductase |
skin |
berry skin, lower level of LAR2 expression than in seed |
676588 |
1.17.3.2 | xanthine oxidase |
skin |
- |
686461, 686881 |
1.17.4.4 | vitamin-K-epoxide reductase (warfarin-sensitive) |
skin |
low expression level |
744945 |
1.2.1.5 | aldehyde dehydrogenase [NAD(P)+] |
skin |
- |
711110 |
1.2.1.84 | alcohol-forming fatty acyl-CoA reductase |
skin |
- |
656242 |
1.2.1.84 | alcohol-forming fatty acyl-CoA reductase |
skin |
and eyelid, tissues with highest expression |
656242 |
1.2.1.84 | alcohol-forming fatty acyl-CoA reductase |
skin |
most abundant in |
656242 |
1.2.3.1 | aldehyde oxidase |
skin |
- |
-, 656258, 656273 |
1.2.3.1 | aldehyde oxidase |
skin |
AOH2 |
691701 |
1.20.4.2 | methylarsonate reductase |
skin |
- |
287856 |
1.21.99.3 | thyroxine 5-deiodinase |
skin |
- |
644800, 689755, 733734, 733907 |
1.21.99.3 | thyroxine 5-deiodinase |
skin |
isozyme type III |
644796 |
1.21.99.4 | thyroxine 5'-deiodinase |
skin |
- |
644806 |
1.21.99.4 | thyroxine 5'-deiodinase |
skin |
isozyme type II |
644806 |
1.3.1.21 | 7-dehydrocholesterol reductase |
skin |
- |
-, 712886 |
1.3.1.22 | 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) |
skin |
- |
396206, 396207, 684816, 712125 |
1.3.1.22 | 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) |
skin |
female breast skin |
656681 |
1.3.1.22 | 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) |
skin |
isozymes 5alphaR-1 and 5alphaR-2, dihydrotestosterone overproduction in skin pathologies, overview |
656656 |
1.3.1.70 | DELTA14-sterol reductase |
skin |
highest expression in sun-exposed skin |
765069 |
1.3.3.6 | acyl-CoA oxidase |
skin |
- |
712822 |
1.3.5.2 | dihydroorotate dehydrogenase (quinone) |
skin |
- |
390925 |