EC Number   |
Recommended Name |
Source Tissue |
Reference |
|---|
   1.1.1.153 | sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) |
substantia nigra |
- |
655138 |
| 1.1.1.315 | 11-cis-retinol dehydrogenase |
substantia nigra |
11% mRNA expression of Rdh5 compared to liver |
690797 |
| 1.1.1.50 | 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) |
substantia nigra |
- |
-, 741098 |
| 1.14.13.39 | nitric-oxide synthase (NADPH) |
substantia nigra |
- |
700432 |
 1.14.15.18 | calcidiol 1-monooxygenase |
substantia nigra |
high enzyme level in large dopaminergic neurons |
659563 |
| 1.14.16.2 | tyrosine 3-monooxygenase |
substantia nigra |
- |
688541, 689215 |
| 1.14.16.2 | tyrosine 3-monooxygenase |
substantia nigra |
contains tyrosine hydroxylase-immunoreactive neurons |
684220 |
| 1.14.99.1 | prostaglandin-endoperoxide synthase |
substantia nigra |
- |
673515 |
| 1.3.1.24 | biliverdin reductase |
substantia nigra |
- |
711794 |
| 1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
substantia nigra |
- |
691774, 691776 |
| 2.3.1.61 | dihydrolipoyllysine-residue succinyltransferase |
substantia nigra |
- |
487343 |
| 2.6.1.7 | kynurenine-oxoglutarate transaminase |
substantia nigra |
pars compacta. Neurons and glial cells. Treatment with 6-hydroxydopamine produces loss of the majority of nigral neurons. KAT-I diminished considerably in the remaining neurons. Astrocytes in the substantia nigra express KAT-I under normal conditions, the amount of this enzyme increases after administration of 6-hydroxydopamine. Microglial cells become KAT-I immunoreactive only after treatment with 6-hydroxydopamine |
671174 |
| 2.7.11.16 | G-protein-coupled receptor kinase |
substantia nigra |
- |
675545 |
| 2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
substantia nigra |
predominant expression of CaMKII isozymes gammaA, gammaC, delta1, and delta3 in dopaminergic neurons |
666122 |
| 2.7.11.31 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase |
substantia nigra |
- |
702079 |
| 3.1.3.16 | protein-serine/threonine phosphatase |
substantia nigra |
- |
655140 |
| 3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase |
substantia nigra |
- |
670448 |
| 3.2.1.45 | glucosylceramidase |
substantia nigra |
- |
749862 |
| 3.3.2.9 | microsomal epoxide hydrolase |
substantia nigra |
- |
699680, 753726 |
| 3.4.19.12 | ubiquitinyl hydrolase 1 |
substantia nigra |
UCHL-1 protein reduced in cases with Lewy body pathology |
666444 |
| 3.4.21.26 | prolyl oligopeptidase |
substantia nigra |
- |
683923 |
| 3.4.21.26 | prolyl oligopeptidase |
substantia nigra |
midbrain |
694399 |
| 3.4.24.11 | neprilysin |
substantia nigra |
distribution of neprilysin is high in the striatum, globus pallidus, and substantia nigra, but very low in the cerebral cortex |
701381 |
| 3.4.25.1 | proteasome endopeptidase complex |
substantia nigra |
localization in nuclei of neurons of the putamen and substantia nigra of Parkinson's disease patients, no nuclear localization is observed in the same areas of brains of controls |
670410 |
| 3.6.1.13 | ADP-ribose diphosphatase |
substantia nigra |
- |
209946 |
| 3.6.1.13 | ADP-ribose diphosphatase |
substantia nigra |
weak |
655991 |
| 4.1.1.15 | glutamate decarboxylase |
substantia nigra |
- |
700470 |
| 4.1.1.28 | aromatic-L-amino-acid decarboxylase |
substantia nigra |
- |
691888 |
| 4.6.1.2 | guanylate cyclase |
substantia nigra |
moderate expression of beta1, alpha subunits expression is very low |
681090 |
| 7.1.1.2 | NADH:ubiquinone reductase (H+-translocating) |
substantia nigra |
- |
693720 |
