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Results 1 - 10 of 25 > >>
EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Commentary Reference
Show all pathways known for 6.3.4.2Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.2-999 - - 690817
Show all pathways known for 6.3.4.2Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.2-999 - a structure-activity study using a variety of GTP and guanosine analogues reveals that only a few GTP analogues are capable of activating Gln-dependent CTP formation to varying degrees: GTP > 6-thio-GTP > ITP> guanosine 5'-tetraphosphate > O-methyl-GTP > 2'-deoxy-GTP. No activation is observed with guanosine, GMP, GDP, 2',3'-dideoxy-GTP, acycloguanosine, and acycloguanosine monophosphate indicating that the 5'-triphosphate, 2'-OH, and 3'-OH are required for full activation. The 2-NH2 group is important in binding recognition while substituents at the 6-position are important in activation. 674909
Show all pathways known for 6.3.4.2Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.2-999 - CTP synthetase 1 activity of the T455A mutant enzyme is 2fold higher than the wild type enzyme. T455A mutation causes a 44% decrease in the amount of human CTP synthetase 1 that is phosphorylated in Saccharomyces cerevisiae cells, accompanied by a 2.5fold increase in the cellular concentration of CTP and a 1.5-fold increase in the choline-dependent synthesis of phosphatidylcholine 674886
Show all pathways known for 6.3.4.2Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.2-999 - during the purification, the specific activity of the enzyme preparation increased 836fold and the total yield is 28% 674786
Show all pathways known for 6.3.4.2Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.2-999 - fast assay allows the processing of a large number of samples 648996
Show all pathways known for 6.3.4.2Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.2-999 - low serum is found to decrease CTPS1 activity, and incubation with the glycogen synthase kinase 3 inhibitor indirubin-3Â’-monoxime protects against this decrease in activity. Incubation with an alkaline phosphatase increases CTPS1 activity in a time-dependent manner, demonstrating that phosphorylation inhibits CTPS1 activity 674862
Show all pathways known for 6.3.4.2Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.2-999 - S462A mutation results in 61%-reduced CTP synthetase 1 phosphorylation. The Saccharomyces cerevisiae-expressed and purified S462A mutant enzyme exhibits a 2fold reduction in CTP synthetase 1 activity, whereas the purified T455A mutant enzyme exhibited a 2fold elevation in CTP synthetase 1 activity, implying that that protein kinase C phosphorylation at Ser462 stimulates human CTP synthetase 1 activity, whereas phosphorylation at Thr455 inhibits activity 674816
Show all pathways known for 6.3.4.2Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.2-999 - T455A mutation results in 58%-reduced CTP synthetase 1 phosphorylation. The Saccharomyces cerevisiae-expressed and purified S462A mutant enzyme exhibits a 2fold reduction in CTP synthetase 1 activity, whereas the purified T455A mutant enzyme exhibited a 2fold elevation in CTP synthetase 1 activity, implying that that protein kinase C phosphorylation at Ser462 stimulates human CTP synthetase 1 activity, whereas phosphorylation at Thr455 inhibits activity 674816
Show all pathways known for 6.3.4.2Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.2-999 - Thr 455 is identified as a major site of phosphorylation by protein kinase A, phosphorylation at Thr455 results in the inhibition of activity in vitro and in vivo. Data indicate that phosphorylation at Thr455 attenuates the choline-dependent synthesis of phosphatidylcholine when CTP synthetase 1 enzyme is expressed in Saccharomyces cerevisiae 674886
Show all pathways known for 6.3.4.2Display the word mapDisplay the reaction diagram Show all sequences 6.3.4.20.00066 - crude extract of protein 674786
Results 1 - 10 of 25 > >>