EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.1.99.24 | L-3-hydroxybutyrate + 2-oxoglutarate |
oxidized at 33% the rate of 4-hydroxybutyrate |
Rattus norvegicus |
acetoacetate + 2-oxoglutarate |
- |
? |
1.1.99.24 | L-3-hydroxybutyrate + 2-oxoglutarate |
oxidized at 33% the rate of 4-hydroxybutyrate |
Rattus norvegicus Sprague-Dawley |
acetoacetate + 2-oxoglutarate |
- |
? |
1.1.99.24 | L-3-hydroxybutyrate + succinic semialdehyde |
- |
Rattus norvegicus |
acetoacetate + 4-hydroxybutyrate |
- |
? |
1.1.99.24 | L-3-hydroxybutyrate + succinic semialdehyde |
oxo-acids that can act as hydrogen acceptors are 2-oxoadipate, 24% as effective as 2-oxoglutarate and oxaloacetate, 19% as effective as 2-oxoglutarate, D-3-hydroxybutyrate, DL-2-hydroxybutyrate, D/L-malate, D/L-lactate, acetoacetate, 3-oxobutyrate, 3-oxoadipate do not act as hydrogen acceptors, poor acceptors are pyruvate and 2-oxobutyrate |
Rattus norvegicus |
acetoacetate + 4-hydroxybutyrate |
- |
? |
1.1.99.24 | L-3-hydroxybutyrate + succinic semialdehyde |
62.5% of activity with D-2-hydroxyglutarate |
Rattus norvegicus |
acetoacetate + 4-hydroxybutyrate |
- |
? |
1.1.99.24 | L-3-hydroxybutyrate + succinic semialdehyde |
oxo-acids that can act as hydrogen acceptors are 2-oxoadipate, 24% as effective as 2-oxoglutarate and oxaloacetate, 19% as effective as 2-oxoglutarate, D-3-hydroxybutyrate, DL-2-hydroxybutyrate, D/L-malate, D/L-lactate, acetoacetate, 3-oxobutyrate, 3-oxoadipate do not act as hydrogen acceptors, poor acceptors are pyruvate and 2-oxobutyrate |
Rattus norvegicus Sprague-Dawley |
acetoacetate + 4-hydroxybutyrate |
- |
? |
1.1.99.24 | L-3-hydroxybutyrate + succinic semialdehyde |
62.5% of activity with D-2-hydroxyglutarate |
Rattus norvegicus Sprague-Dawley |
acetoacetate + 4-hydroxybutyrate |
- |
? |
1.1.99.24 | more |
D-2-hydroxyglutaric aciduria is not associated to the enzyme activity |
Homo sapiens |
? |
- |
? |