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EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
1.1.1.247
codeine + NADP+
-
Papaver somniferum
codeinone + NADPH + H+
-
r
1.1.1.247
Codeinone + NADPH
-
Papaver somniferum
Codeine + NADP+
-
?
1.1.1.247
Codeinone + NADPH
-
Papaver somniferum
Codeine + NADP+
-
r
1.1.1.247
Codeinone + NADPH
r
Papaver somniferum
Codeine + NADP+
-
?
1.1.1.247
Codeinone + NADPH
r
Papaver somniferum
Codeine + NADP+
(-)codeine
?
1.1.1.247
Codeinone + NADPH
(-)codeinone
Papaver somniferum
Codeine + NADP+
(-)codeine
?
1.1.1.247
Codeinone + NADPH
no reaction with NADH and NAD+
Papaver somniferum
Codeine + NADP+
-
?
1.1.1.247
Codeinone + NADPH
no reaction with NADH and NAD+
Papaver somniferum
Codeine + NADP+
(-)codeine
?
1.1.1.247
Codeinone + NADPH
neopinone, which is formed most likely by demethylation of the vinylether of thebaine exists in the plant cell in a thermodynamic equilibrium with codeinone. The presence of the codeinone reductase/NADPH system shifts this equilibrium quantitatively in the direction of codeine, which either accumulates in the latex of the poppy plant or is further demethylated at the 3-OCH3 group yielding morphine
Papaver somniferum
Codeine + NADP+
-
?
1.1.1.247
Codeinone + NADPH
biosynthesis of codeine
Papaver somniferum
Codeine + NADP+
-
?
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