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EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
1.1.1.286
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+
chemical mechanism, stereochemistry of hydride transfer to NAD, overview
Saccharomyces cerevisiae
2-oxoadipate + CO2 + NADH + H+
-
?
1.1.1.286
3-isopropylmalate + NAD+
at 0.1% of the rate with homoisocitrate
Deinococcus radiodurans
?
-
?
1.1.1.286
3-isopropylmalate + NAD+
-
Thermococcus kodakarensis
2-oxoisocaproate + CO2 + NADH + H+
-
?
1.1.1.286
3-isopropylmalate + NAD+
-
Thermococcus kodakarensis KRD1
2-oxoisocaproate + CO2 + NADH + H+
-
?
1.1.1.286
homoisocitrate + NAD+
-
Saccharomyces cerevisiae
? + NADH
-
?
1.1.1.286
homoisocitrate + NAD+
-
Pyrococcus horikoshii
? + NADH
-
?
1.1.1.286
homoisocitrate + NAD+
-
Thermus thermophilus
? + NADH
-
?
1.1.1.286
homoisocitrate + NAD+
1.5fold preferred over isocitrate
Deinococcus radiodurans
? + NADH
-
?
1.1.1.286
homoisocitrate + NAD+
-
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
? + NADH
-
?
1.1.1.286
homoisocitrate + NAD+
-
Thermus thermophilus
2-oxoadipate + CO2 + NADH + H+
-
r
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