EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.11.26 | 3'-methylcephem + 2-oxoglutarate + O2 |
- |
Amycolatopsis lactamdurans |
3'-hydroxymethylcephem + succinate + CO2 |
- |
? |
1.14.11.26 | 3-exo-methylenecephalosporin C + 2-oxoglutarate + O2 |
37% of activity with deacetoxycephalosporin C |
Streptomyces clavuligerus |
deacetoxycephalosporin C + succinate + CO2 |
- |
? |
1.14.11.26 | 3-exomethylenecephalosporin + 2-oxoglutarate + O2 |
- |
Actinomyces sp. |
deacetoxycephalosporin C + succinate + CO2 + H2O |
- |
? |
1.14.11.26 | 3-exomethylenecephalosporin C + 2-oxoglutarate + O2 |
- |
Streptomyces clavuligerus |
deacetylcephalosporin C + succinate + CO2 + H2O |
- |
? |
1.14.11.26 | 7-aminodeacetoxycephalosporanic acid + 2-oxoglutarate + O2 |
- |
Acremonium chrysogenum |
7-aminodeacetylcephalosporin + succinate + CO2 |
- |
? |
1.14.11.26 | 7-aminodeacetoxycephalosporanic acid + 2-oxoglutarate + O2 |
poor substrate |
Acremonium chrysogenum |
7-aminodeacetylcephalosporin + succinate + CO2 |
- |
? |
1.14.11.26 | ampicillin + 2-oxoglutarate + O2 |
- |
Streptomyces clavuligerus |
? + succinate + CO2 |
- |
? |
1.14.11.26 | cephalexin + 2-oxoglutarate + O2 |
- |
Acremonium chrysogenum |
? + succinate + CO2 |
- |
? |
1.14.11.26 | cephalosporin G + 2-oxoglutarate + O2 |
the wild-type enzyme shows negligible activity toward cephalosporin G, an unnatural and less expensive substrate analogue, but diverse enzyme mutants show increased to high activity with cephalosporin G, overview |
Streptomyces clavuligerus |
deacetylcephalosporin G + succinate + CO2 |
- |
? |
1.14.11.26 | cephalosporin G + 2-oxoglutarate + O2 |
the wild-type enzyme shows negligible activity toward cephalosporin G, an unnatural and less expensive substrate analogue, but diverse enzyme mutants show increased to high activity with cephalosporin G, overview |
Streptomyces clavuligerus ATCC 27064 |
deacetylcephalosporin G + succinate + CO2 |
- |
? |