EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.11.51 | more |
ALKBH1 prefers bubbled or bulged DNAs as substrate. The middle N6-mA in the 3-nt bulge is efficiently demethylated compared to that in the 3-nt bubble (97% vs. 18% demethylation fraction) and the 1st and 3rd N6-mAs are more resistant to demethylation. N6-mAs deposited in the flexible region of hairpin (DNA stem loop), D-loop and R-loop are efficiently demethylated as in bubble and bulge, while those in cruciform and replication fork are less demethylated. m6rA in RNA hairpin, RNA-RNA bubble and RNA-DNA hybrid bubble can also be demethylated by ALKBH1, as well as 5-methylcytosine at anticodon loop and 1-methyladenosine |
Mus musculus |
? |
- |
- |
1.14.11.51 | N6-methyladenine in DNA + 2-oxoglutarate + O2 |
- |
Drosophila melanogaster |
adenine in DNA + formaldehyde + succinate + CO2 |
- |
? |
1.14.11.51 | N6-methyladenine in DNA + 2-oxoglutarate + O2 |
- |
Homo sapiens |
adenine in DNA + formaldehyde + succinate + CO2 |
- |
? |
1.14.11.51 | N6-methyladenine in DNA + 2-oxoglutarate + O2 |
- |
Caenorhabditis elegans |
adenine in DNA + formaldehyde + succinate + CO2 |
- |
? |
1.14.11.51 | N6-methyladenine in DNA + 2-oxoglutarate + O2 |
- |
Mus musculus |
adenine in DNA + formaldehyde + succinate + CO2 |
- |
? |
1.14.11.51 | N6-methyladenine in DNA + 2-oxoglutarate + O2 |
the enzyme catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons |
Mus musculus |
adenine in DNA + formaldehyde + succinate + CO2 |
- |
? |