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Results 1 - 4 of 4

EC Number	Substrates	Commentary Substrates	Organism	Products	Commentary (Products)	Reversibility
1.14.13.154	erythromycin B + NADPH + H+ + O2	1200-1900-fold preference for erythromycin D over the alternative C-12 hydroxylase substrate erythromycin B	Saccharopolyspora erythraea	erythromycin A + NADP+ + H2O	-	?
1.14.13.154	erythromycin D + NADPH + H+ + O2	-	Saccharopolyspora erythraea	erythromycin C + NADP+ + H2O	-	?
1.14.13.154	erythromycin D + NADPH + H+ + O2	1200-1900-fold preference for erythromycin D over the alternative C-12 hydroxylase substrate erythromycin B	Saccharopolyspora erythraea	erythromycin C + NADP+ + H2O	-	?
1.14.13.154	more	in a Saccharopolyspora venezuelae pikC deletion mutant, EryK can catalyze the hydroxylation of YC-17 and narbomycin to generate methymycin/neomethymycin and pikromycin, respectively. EryK is flexible toward some alternative polyketides and can be useful for structural diversification of macrolides by post-polyketide synthase hydroxylation	Saccharopolyspora erythraea	?	-	?

Results 1 - 4 of 4

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Release 2023.1 (January 2023)