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Results 1 - 9 of 9
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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.225more the Km for NADPH of the NADPH oxidase reaction is sensitive to ionic strength and type of ions. The apparent kcat (pH 7) is limited by enzyme reduction by NADPH, which occurs without detectable intermediates. The reaction is also sensitive to solvent viscosity Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.225more the reductive half-reaction of the mical2 hydroxylase domain is stimulated by F-actin. In the absence of actin, NADPH reduces the flavin relatively slowly. Actin speeds that reaction significantly. The separate monooxygenase domain has the classic regulatory behavior of flavin-dependent aromatic hydroxylases (Class A monooxygenases) with slow reduction of the flavin when the substrate to be oxygenated is absent Mus musculus ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.225more MICAL has additionally NADPH oxidase activity that underlies F-actin disassembly simultaneously with the oxidation of NADPH. For MICAL3 containing the FMO and CH domains, the kcat/Km ratio for NADPH oxidase activity increases dramatically on adding F-actin, while the kcat/Km value for MICAL3 lacking the CH domain changes little Homo sapiens ? - -
Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.225[F-actin]-L-methionine + NADH + O2 + H+ - Homo sapiens [F-actin]-L-methionine-(R)-S-oxide + NAD+ + H2O - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.225[F-actin]-L-methionine + NADPH + O2 + H+ - Homo sapiens [F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.225[F-actin]-L-methionine + NADPH + O2 + H+ - Mus musculus [F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.225[F-actin]-L-methionine + NADPH + O2 + H+ - Drosophila melanogaster [F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O Mical post-translationally oxidizes the methionine 44 residue within the D-loop of actin, simultaneously severing filaments and decreasing polymerization ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.225[F-actin]-L-methionine + NADPH + O2 + H+ - Homo sapiens [F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O only 2-3 residues are oxidized in each actin monomer. Several residues, including Met44 and Met47, are modified with similar probability ?
Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.225[F-actin]-L-methionine + NADPH + O2 + H+ usage of F-actin from rabbit skeletal muscle purified from G-actin by ultracentrifugation Homo sapiens [F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O - ?
Results 1 - 9 of 9
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