EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.19.51 | (R,S)-codamine + [reduced NADPH-hemoprotein reductase] + O2 |
- |
Coptis japonica |
2,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,10-diol + [oxidized NADPH-hemoprotein reductase] + 2 H2O |
12% of the activity with reticuline. The major product is (R,S)-orientaline, 4'-O-demethylation product of (R,S)-codamine, and the minor one is proposed to be the same compound as (R,S)-orientaline-derived phenol coupling product |
? |
1.14.19.51 | (R,S)-norreticuline + [reduced NADPH-hemoprotein reductase] + O2 |
- |
Coptis japonica |
2,10-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,11-diol + [oxidized NADPH-hemoprotein reductase] + 2 H2O |
19% of the activity with reticuline |
? |
1.14.19.51 | (S)-N-methylcoclaurine + [reduced NADPH-hemoprotein reductase] + O2 |
- |
Coptis japonica |
2,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,10-diol + [oxidized NADPH-hemoprotein reductase] + 2 H2O |
2% of the activity with reticuline |
? |
1.14.19.51 | (S)-orientaline + [reduced NADPH-hemoprotein reductase] + O2 |
- |
Coptis japonica |
2,11-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,10-diol + [oxidized NADPH-hemoprotein reductase] + 2 H2O |
2.7% of the activity with reticuline |
? |
1.14.19.51 | (S)-reticuline + [reduced NADPH-hemoprotein reductase] + O2 |
- |
Coptis japonica |
(S)-corytuberine + [oxidized NADPH-hemoprotein reductase] + 2 H2O |
- |
? |
1.14.19.51 | more |
CĀC phenol-coupling reaction, requires NADPH and oxygen. The enzyme is specific for S-enantiomer of substrate |
Coptis japonica |
? |
- |
? |