EC Number   |
Cofactor |
Reference |
|---|
    1.2.1.22 | more |
NADP+ can not substitute for NAD+ |
288132, 288135 |
| 1.2.1.22 | more |
no activity with NADP+ |
697876 |
| 1.2.1.22 | more |
the negatively charged carboxylate group of E179 destabilizes the binding of the 2'-phosphate group of NADPH sterically and electrostatically, thereby accounting for the lack of enzyme activity with this cofactor |
675430 |
| 1.2.1.22 | NAD+ |
- |
287313, 287315, 288131, 288132, 288134, 288135, 288136, 670833, 697876, 740187, 742119, 762979 |
| 1.2.1.22 | NAD+ |
ALD only uses NAD+. Residue F180 of ALD may participate in coenzyme specificity |
695015 |
| 1.2.1.22 | NAD+ |
cofactor flexibility in the constricted active site plays a significant role in the mechanism of oxidation of lactaldehyde to lactate |
675430 |
| 1.2.1.22 | NAD+ |
dependent on |
692329 |
| 1.2.1.22 | NAD+ |
four NAD-binding sites per molecule of native enzyme |
288133 |
| 1.2.1.22 | NADP+ |
- |
697876, 743302 |
