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Results 1 - 4 of 4
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EC Number Cofactor Commentary Reference
Display the reaction diagram Show all sequences 2.1.1.326methylcob(III)alamin methyl donor of the reaction 738468
Display the reaction diagram Show all sequences 2.1.1.326methylcob(III)alamin NMR results support a reaction mechanism in which methylcob(III)alamin is the direct methyl group donor 738957
Display the reaction diagram Show all sequences 2.1.1.326methylcob(III)alamin the enzyme catalyzes P-methylation using radical S-adenosyl-L-methionine-dependent chemistry with cobalamin as a coenzymemethyl donor of the reaction. The enzyme is active in the absence of methylcobalamin if the strong reductant titanium(III)citrate and hydroxocobalamin are provided 737755
Display the reaction diagram Show all sequences 2.1.1.326methylcob(III)alamin the enzyme is a radical S-adenosyl-L-methionine enzyme that contains a [4Fe-4S] center and a methylcob(III)alamin cofactor. According to the proposed mechanism, the reduced iron-sulfur center donates an electron to S-adenosyl-L-methionine, resulting in homolytic cleavage of the carbon-sulfur bond to form a 5'-deoxyadenosyl radical that abstracts the hydrogen atom from the P-H bond of the substrate, forming a phosphinate-centered radical. This radical reacts with methylcob(III)alamin to produce the methylated product and cob(II)alamin, which is reduced by an unknown donor to cob(I)alamin. A potential route for restoring the latter back to methylcob(III)alamin is a nucleophilic attack on a second S-adenosyl-L-methionine molecule 735668
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