EC Number |
Cofactor |
Reference |
---|
2.5.1.61 | dipyrromethane |
- |
685506, 707428, 737372, 737881, 739392 |
2.5.1.61 | dipyrromethane |
cofactor assembly mechanism, R149 and R173 are important, cofactor is produced from the apo-enzyme with pre-uroporphyrinogen |
661042 |
2.5.1.61 | dipyrromethane |
in active site as shown by using Ehrlich's reagent |
696120 |
2.5.1.61 | dipyrromethane |
the active site possesses the unusual dipyrromethane cofactor which is extended during the reaction by the sequential addition of the four substrate molecules. The cofactor is linked covalently to the enzyme through a thioether bridge to the invariant Cys254, binding structure, overview. Hydrolysis of the linkage between the first substrate moiety and the cofactor releases the tetrapyrrole product preuroporphyrinogen. The dipyrromethane cofactor of enzyme PBGD is light-sensitive |
737341 |
2.5.1.61 | dipyrromethane |
the addition of one molecule of porphobilinogen to the dipyrromethane cofactor is carried out in four steps: protonation of the substrate, porphobilinogen, deamination of porphobilinogen, electrophilic addition of the deaminated substrate to the terminal pyrrole ring of the enzyme-bound dipyrromethane cofactor and deprotonation of the carbon atom at the alpha-position of the second ring of dipyrromethane |
759911 |
2.5.1.61 | dipyrromethane |
the enzyme possesses a dipyrromethane cofactor, which is covalently linked by a thioether bridge to the invariant cysteine residue, Cys241. The cofactor extends during the reaction by the sequential addition of the four substrate molecules, which are released as a linear tetrapyrrole product. Structure determination of the oxidized form of the dipyrromethane cofactor covalently attached to Cys241, overview. Analysis of oxidation states of the dipyrromethane cofactor and a proposed mechanism for oxidation of the dipyrromethane to dipyrromethene and subsequently dipyrromethanone |
737348 |
2.5.1.61 | dipyrromethane |
the residues of the domains 1 and 2 interact with the cofactor in a coordinated way to facilitate the catalytic activity |
759637 |