EC Number   |
Cofactor |
Reference |
|---|
    2.5.1.72 | 4Fe-4S-center |
inhibitor 4,5-dithiohydroxyphthalic acid coordinates to the enzyme [4Fe-4S] cluster through a differentiated iron site |
721290 |
| 2.5.1.72 | iron-sulfur centre |
enzyme carries a higly oxygen-sensiteve [4Fe-4S] cluster at the NadA domain |
687563 |
| 2.5.1.72 | iron-sulfur centre |
enzyme contains a [4Fe-4S]-cluster, coordinated by residues C110, C230, C320. 3.8 mol iron per mol of enzyme, 3.3 mol sulfur per mol of enzyme |
686712 |
| 2.5.1.72 | iron-sulfur centre |
protein contains 3-3.5 mol iron and 3-3.5 mol sulfur per mol. Majority of the iron is in the form of a [4Fe-4S]2+ cluster. The cluster is absolutely required for activity |
686715 |
| 2.5.1.72 | iron-sulfur centre |
protein contains 4 mol of iron and sulfur per mol |
686766 |
| 2.5.1.72 | iron-sulfur centre |
protein contains a [4Fe-4S] cluster absolutely required for activity |
685193 |
| 2.5.1.72 | iron-sulfur centre |
protein contains a [4Fe-4S]2+ cluster plus a small amount of a [3Fe-4S]+ cluster species. Protein contains 5 mol of iron and 2.8 mol of sulfur per mol |
687273 |
| 2.5.1.72 | iron-sulfur centre |
sequence contains a Cys-W-X-Cys-Y-Z-Cys sequence characteristic for (Fe-S)4-containing proteins. Enzyme is inhibited by Fe(II)-chelating agents |
684659 |
| 2.5.1.72 | [4Fe-4S]-center |
inhibitors 4-mercaptophthalic acid, 6-mercaptopyridine-2,3-dicarboxylic acid and 5-mercaptopyrazine-2,3-dicarboxylic acid bind to the catalytic iron site of the [4Fe-4S] cluster through their thiolate |
759045 |
| 2.5.1.72 | [4Fe-4S]-center |
NadA contains a [4Fe-4S] cluster cofactor with a unique, non-cysteinyl-ligated, iron ion (Fea), which binds the hydroxyl group of a postulated intermediate in the last step of the reaction to facilitate a dehydration. N1 and the C7 carboxylate group of quinolinate ligate to Fea in a bidentate fashion placing the C5 hydroxyl group of the postulated final intermediate distal to Fea and virtually incapable of coordinating to it |
738460 |
