1.4.1.27 | structure of component T-protein, at 1.5 A resolution. The dimeric state might be essential for the function. The role of residue Glu100 might be the activation of the N10 atom of tetrahodrofolate by increasing its nucleophilic character. The H-protein-T-protein interface includes invariant residues Arg327, Tyr330, and Arg376 of domain III, and Lys20, Phe24, Gly26, Ser35, Ile36, Leu248, Gly249, Asp252, Thr253, Arg255, and Leu262 of domains I and II |