EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category  |
Confidence Level |
|---|
    2.5.1.29 | Liver Diseases |
29971772 |
Geranylgeranyl diphosphate synthase (GGPPS) regulates non-alcoholic fatty liver disease (NAFLD)-fibrosis progression by determining hepatic glucose/fatty acid preference under high-fat diet conditions. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
2
3
1
0 |
| 2.5.1.29 | Lung Injury |
31874250 |
Geranylgeranyl diphosphate synthase 1 knockout ameliorates ventilator-induced lung injury via regulation of TLR2/4-AP-1 signaling. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
4
2
1 |
| 2.5.1.29 | Neoplasm Metastasis |
29377583 |
Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
4
4
2 |
| 2.5.1.29 | Acute Lung Injury |
34530204 |
Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
1
3
3
2 |
| 2.5.1.29 | Adenocarcinoma of Lung |
29377583 |
Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
4
4
2 |
| 2.5.1.29 | Breast Neoplasms |
20480384 |
Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
1
3
4 |
| 2.5.1.29 | Carcinoma, Hepatocellular |
24716791 |
GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
4
4
1 |
| 2.5.1.29 | geranylgeranyl diphosphate synthase deficiency |
31120854 |
Geranylgeranyl diphosphate synthase deficiency aggravates lung fibrosis in mice by modulating TGF-?1/BMP-4 signaling. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
2
4
0 |
| 2.5.1.29 | Hyperinsulinism |
24716791 |
GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
4
4
1 |
| 2.5.1.29 | Liver Neoplasms |
24716791 |
GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
4
4
1 |
