EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
    1.5.5.2 | 22q11 Deletion Syndrome |
18989458 |
Functional polymorphisms in PRODH are associated with risk and protection for schizophrenia and fronto-striatal structure and function. |
causal interaction
therapeutic application
unassigned |
2
1
0 |
| 1.5.5.2 | 22q11 Deletion Syndrome |
26068888 |
PRODH rs450046 and proline x COMT Val¹?? Met interaction effects on intelligence and startle in adults with 22q11 deletion syndrome. |
ongoing research
therapeutic application
unassigned |
1
1
0 |
| 1.5.5.2 | Brain Neoplasms |
34089390 |
N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
1
2
3
2 |
| 1.5.5.2 | Breast Neoplasms |
25184115 |
Sources of superoxide/H2O2 during mitochondrial proline oxidation. |
causal interaction
ongoing research
therapeutic application
unassigned |
3
4
2
0 |
| 1.5.5.2 | Breast Neoplasms |
28492237 |
Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
2
4
0 |
| 1.5.5.2 | Breast Neoplasms |
28942439 |
Functional Consequences of Intracellular Proline Levels Manipulation Affecting PRODH/POX-Dependent Pro-Apoptotic Pathways in a Novel in Vitro Cell Culture Model. |
ongoing research
unassigned |
4
0 |
| 1.5.5.2 | Breast Neoplasms |
29568391 |
Proline oxidase silencing induces proline-dependent pro-survival pathways in MCF-7 cells. |
ongoing research
unassigned |
3
0 |
| 1.5.5.2 | Breast Neoplasms |
31189611 |
Targeting Mitochondrial Proline Dehydrogenase with a Suicide Inhibitor to Exploit Synthetic Lethal Interactions with p53 Upregulation and Glutaminase Inhibition. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 1.5.5.2 | Breast Neoplasms |
31559416 |
HDAC inhibitors induce proline dehydrogenase (POX) transcription and anti-apoptotic autophagy in triple negative breast cancer. |
causal interaction
unassigned |
2
0 |
| 1.5.5.2 | Carcinogenesis |
22886911 |
Proline dehydrogenase (oxidase) in cancer. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
