EC Number |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
---|
2.5.1.29 | Acute Lung Injury |
30652497 |
Inhibition of GGPPS1 attenuated LPS-induced acute lung injury and was associated with NLRP3 inflammasome suppression. |
ongoing research therapeutic application unassigned |
3 2 0 |
2.5.1.29 | Acute Lung Injury |
33729030 |
Geranylgeranyl diphosphate synthase deficiency hyperactivates macrophages and aggravates lipopolysaccharide-induced acute lung injury. |
causal interaction therapeutic application unassigned |
4 1 0 |
2.5.1.29 | Acute Lung Injury |
34530204 |
Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury. |
causal interaction diagnostic usage ongoing research therapeutic application |
1 3 3 2 |
2.5.1.29 | Adenocarcinoma |
30918331 |
Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma. |
causal interaction therapeutic application unassigned |
4 4 0 |
2.5.1.29 | Adenocarcinoma of Lung |
29377583 |
Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 4 4 2 |
2.5.1.29 | Ataxia |
31570763 |
Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition. |
ongoing research therapeutic application unassigned |
4 3 0 |
2.5.1.29 | Azoospermia |
31171774 |
The alteration of RhoA geranylgeranylation and Ras farnesylation breaks the integrity of the blood-testis barrier and results in hypospermatogenesis. |
causal interaction diagnostic usage unassigned |
3 1 0 |
2.5.1.29 | Bone Resorption |
21419634 |
Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase. |
causal interaction diagnostic usage therapeutic application unassigned |
1 1 4 0 |
2.5.1.29 | Breast Neoplasms |
20480384 |
Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration. |
causal interaction diagnostic usage ongoing research therapeutic application |
3 1 3 4 |
2.5.1.29 | Breast Neoplasms |
21335425 |
Bisphosphonates Induce Autophagy by Depleting Geranylgeranyl Diphosphate. |
diagnostic usage ongoing research therapeutic application unassigned |
1 1 1 0 |