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Results 1 - 5 of 5
EC Number
Amino acid exchange
Commentary
Reference
E509A/E512A/E513A
mutation in isoform Atf1, mutated protein shows 84% localization to lipid droplets
L511A/L514A/Y518A/L512A
mutation in isoform Atf1, loss of membrane association
more
truncation of amphipathic helices within the N- and C-terminal domains of isoform Atf1 (residues 24-41 and 508-525) impair endoplasmic reticulum localization and membrane association. Mutations of the basic or hydrophobic residues in the N-terminal helix and hydrophobic residues in the C-terminal helix of Atf1 disrupt ER association and subsequent sorting from the ER to lipid droplets. Similar amphipathic helices are found at both ends of isoform Atf2, enabling ER and lipid droplet association. Mutations to the N- and C-terminal helices of Atf2 prevent membrane association
R22A/R23A/R36A
mutation in isoform Atf2, protein is localized in the cytoplasm
W518A/F521/I529A/F532A R36A
mutation in isoform Atf2, protein is localized in the cytoplasm
Results 1 - 5 of 5