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Results 1 - 10 of 29 > >>
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EC Number Protein Variants Commentary Reference
Show all pathways known for 1.1.1.6Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.6A15T/D16G/V17A/N19K/E23D/Q45E/S46E/T47M/V48L/E49R/F52L/K53A/V58A/V59A/Q70H/D74N/G78D/E81G/T82N/Q83K/G86T/I88V/G108N/R139S/L142M/N145R/K155Q/V256I/L260M mutant selected from a DNA shuffling library (Escherichia coli, Salmonella enterica, Klebsiella pneumoniae) 710980
Show all pathways known for 1.1.1.6Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.6D121A D121 can potentially hinder the proper binding of substrate 1,3-butanediol due to steric hindrance 710980
Show all pathways known for 1.1.1.6Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.6D121N mutation lowers the activity of the enzyme with most all the tested substrates relative to the native enzyme 762346
Show all pathways known for 1.1.1.6Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.6D121N/F245S mutant acquires D-lactate dehydrogenase activiy, the alteration increases the capacity of the glycerol binding site and facilitated hydrogen bonding between the S245 gamma-O and the C1 carboxylate of pyruvate 762346
Show all pathways known for 1.1.1.6Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.6D123N mutation abolishes the oxidative activity. The carboxylate of D123 is the base needed for abstracting the proton to form the alkoxy intermediate that precedes the hydride transfer to the nicotinamide cofactor 760880
Show all pathways known for 1.1.1.6Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.6D16N/N19A/E23D/L28M/E30N/R31N/Q45E/S46E/V48L/E49R/F52L/K53T/D54G/V58S/G78V/I79V/T82K/A83S/I88V/G108N/R139S/L142M/N145R/K155Q/L211I/G248S/V256I/H268Y/D317E/P319L mutant selected from a DNA shuffling library (Escherichia coli, Salmonella enterica, Klebsiella pneumoniae) 710980
Show all pathways known for 1.1.1.6Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.6F245S mutant acquires D-lactate dehydrogenase activiy, the alteration increases the capacity of the glycerol binding site and facilitated hydrogen bonding between the S245 gamma-O and the C1 carboxylate of pyruvate 762346
Show all pathways known for 1.1.1.6Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.6I154A site-directed mutagenesis, the mutant shows altered activity with cofactor derivative N6-CM-NAD+ immobilized on Sepharose beads compared to the wild-type enzyme -, 739941
Show all pathways known for 1.1.1.6Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.6I154A/K157G site-directed mutagenesis, the mutant shows altered activity with cofactor derivative N6-CM-NAD+ immobilized on Sepharose beads compared to the wild-type enzyme 739941
Show all pathways known for 1.1.1.6Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.6I154A/K157N site-directed mutagenesis, the mutant shows altered activity with cofactor derivative N6-CM-NAD+ immobilized on Sepharose beads compared to the wild-type enzyme 739941
Results 1 - 10 of 29 > >>
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