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Protein Variants:
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EC Number
Protein Variants
Commentary
Reference
1.13.11.53
D101A
about 60% of wild-type activity
685212
1.13.11.53
E100A
about 2% of wild-type activity. E100 is not essential for metal binding
685212
1.13.11.53
E102A
no catalytic activity
685212
1.13.11.53
E94A
no activity
673849
1.13.11.53
E94A
the mutant has an increased percentage of apoptotic cells similar to those expressing wild type enzyme
764433
1.13.11.53
E95A
about 4% of wild-type activity
685212
1.13.11.53
H133A
the mutation at the metal-binding site abolishes both functions of the enzyme in cell growth inhibition and apoptosis enhancement
764433
1.13.11.53
H140A
no catalytic activity
685212
1.13.11.53
H140F
no catalytic activity
685212
1.13.11.53
H96A
no catalytic activity
685212
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