EC Number |
Protein Variants |
Reference |
---|
1.14.11.51 | C118A |
m6A demethylase activity similar to wild-type, about 25% decrease in apurinic/apyrimidinic lyase activity |
764135 |
1.14.11.51 | C118A/C129A |
about 50% decrease in m6A demethylase activity, about 20% decrease in apurinic/apyrimidinic lyase activity |
764135 |
1.14.11.51 | C129A |
about 90% decrease in m6A demethylase activity, about 30% decrease in apurinic/apyrimidinic lyase activity |
764135 |
1.14.11.51 | D186A |
inactive |
742235 |
1.14.11.51 | D233A |
no residual m6A demethylase activity, about 30% decrease in apurinic/apyrimidinic lyase activity |
764135 |
1.14.11.51 | D233A |
reduced activity of the recombinant mutant protein |
736883 |
1.14.11.51 | D233A |
residue plays an important role in substrate recognition and catalysis |
764114 |
1.14.11.51 | H113A/C118A/C129A/H134A |
no residual m6A demethylase activity, about 55% decrease in apurinic/apyrimidinic lyase activity |
764135 |
1.14.11.51 | H231A |
no residual m6A demethylase activity, about 20% decrease in apurinic/apyrimidinic lyase activity |
764135 |
1.14.11.51 | H231A |
residue plays an important role in substrate recognition and catalysis |
764114 |