EC Number   |
Protein Variants |
Reference |
|---|
    1.17.4.4 | A143V |
mutant shows about 140% relative VKOR activity as compared to the wild type enzyme |
696976 |
| 1.17.4.4 | A26P |
the IC50 ratio of wild-type to mutant enzyme is 49.6 |
744586 |
| 1.17.4.4 | A26S |
mutant shows about 70% relative VKOR activity as compared to the wild type enzyme |
696976 |
| 1.17.4.4 | A26T |
mutant shows about 60% relative VKOR activity as compared to the wild type enzyme |
696976 |
| 1.17.4.4 | A26T |
the IC50 ratio of wild-type to mutant enzyme is 3.0 |
744586 |
| 1.17.4.4 | A26T |
the mutation has only a moderate effect on VKOR activity with a reduction to approximately 56% of wild type activity |
696976 |
| 1.17.4.4 | A48T |
mutant shows about 120% relative VKOR activity as compared to the wild type enzyme |
696976 |
| 1.17.4.4 | C101A |
formation of of a high-molecular-weight complex that is positive for thiol-disulfide oxidoreductase MdbA and vitamin K epoxide reductase |
745224 |
| 1.17.4.4 | C1173T |
a single nucleotide polymorphism, SNP, for haplotypes associated with a lower oral anticoagulant dose requirement |
675699 |
| 1.17.4.4 | C1173T |
natural genetic polymorphism of the enzyme in a Chinese and a Caucasian population, genotyping, the exchange for T at position 1173 in asian patients results in a phenotype with higher sensitivity to oral anticoagulants, overview |
671681 |
