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EC Number Protein Variants Commentary Reference
Show all pathways known for 1.2.7.4Display the word mapDisplay the reaction diagram Show all sequences 1.2.7.4A110C alpha subunit mutant enzyme showing electron paramagnetic resonance spectrum after Ni-activation 687824
Show all pathways known for 1.2.7.4Display the word mapDisplay the reaction diagram Show all sequences 1.2.7.4A110C mutation within tunnel region of alpha subunit, absence of strong cooperative inhibition of CO, no synthesis of acetyl-CoA 655801
Show all pathways known for 1.2.7.4Display the word mapDisplay the reaction diagram Show all sequences 1.2.7.4A121H/H122A 11% of wild type activity 654754
Show all pathways known for 1.2.7.4Display the word mapDisplay the reaction diagram Show all sequences 1.2.7.4A219F mutant designed to block tunnel between Ni-Fe-S active site clusters, little enzymic activity. Metal clusters are properly assembled, impaired ability of CO to migrate through the tunnel 674925
Show all pathways known for 1.2.7.4Display the word mapDisplay the reaction diagram Show all sequences 1.2.7.4A222L alpha subunit mutant enzyme showing electron paramagnetic resonance spectrum after Ni-activation 687824
Show all pathways known for 1.2.7.4Display the word mapDisplay the reaction diagram Show all sequences 1.2.7.4A222L mutation within tunnel region of alpha subunit, absence of strong cooperative inhibition of CO, no synthesis of acetyl-CoA 655801
Show all pathways known for 1.2.7.4Display the word mapDisplay the reaction diagram Show all sequences 1.2.7.4A265M mutation within tunnel region of alpha subunit, absence of strong cooperative inhibition of CO, little synthesis of acetyl-CoA 655801
Show all pathways known for 1.2.7.4Display the word mapDisplay the reaction diagram Show all sequences 1.2.7.4A578C mutant designed to block tunnel between Ni-Fe-S active site clusters, little enzymic activity. Metal clusters are properly assembled, impaired ability of CO to migrate through the tunnel 674925
Show all pathways known for 1.2.7.4Display the word mapDisplay the reaction diagram Show all sequences 1.2.7.4C316S 0.3% of wild type activity 654754
Show all pathways known for 1.2.7.4Display the word mapDisplay the reaction diagram Show all sequences 1.2.7.4C338A complete loss of activity. Unable to grow in the dark with CO as the energy source, amount of enzyme present in membrane fraction is similar to wild-type as well as accumulation of Ni2+ 674921
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