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EC Number
Protein Variants
Commentary
Reference
1.3.1.91
C117A
rate constant is 1600fold lower than the rate constant of the wild-type enzyme
712368
1.3.1.91
E294K
the mutation increases the tRNA binding affinity and dihydrouridine activity compared to the wild type enzyme
764155
1.3.1.91
E294K/Q305K
the mutation increases the tRNA binding affinity and dihydrouridine activity compared to the wild type enzyme
764155
1.3.1.91
more
siRNA-dependent knockdown of hDus2 decreases colony formation and cell viability of non-small cell lung cancer cells, while hDus2 immunohistochemical staining correlated with patient survival
743940
1.3.1.91
Q305K
the mutation increases the tRNA binding affinity and dihydrouridine activity compared to the wild type enzyme
764155
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