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Results 1 - 10 of 94 > >>
EC Number Protein Variants Commentary Reference
Show all pathways known for 4.1.1.7Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.7A460G mutant exhibits a higher Km value compared to the wild type enzyme 691794
Show all pathways known for 4.1.1.7Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.7A460I activity with pyruvate is higher than wild-type activity, activity with 2-oxobutanoic acid is 2.3fold higher than wild-type activity, activity with 2-oxopentanoic acid is 1.1fold lower than wild-type activity, activity with 2-oxohexanoic acid is 3.3fold higher than wild-type activity, activity with 3-methyl-2-oxobutanoic acid is 1.3fold higher than wild-type activity, activity with 3-methyl-2-oxopentanoic acid is 1.1fold lower than wild-type activity, activity with 2-oxo-4-methylpentanoic acid is 1.3fold higher than wild-type activity, activity with 4,4-dimethyl-2-oxopentanoic acid is identical to wild-type activity, activity with 2-oxo-4-methylhexanoic acid is 2.2fold higher than wild-type activity, activity with benzoylformate is 22.5fold lower than wild-type activity, activity with 2-oxo-3-phenylpropanoic acid is identical to wild-type activity, activity with 2-oxo-4-phenylbutanoic acid is 1.8fold higher than wild-type activity, activity with 2-oxo-5-phenylpentanoic acid is identical to wild-type activity. The ratio of turnover number to KM-value for 2-oxo-4-methylpentanoic acid is 10fold higher than the wild-type value, the ratio of turnover number to KM-value for 2-oxo-4-methylhexanoic acid is 1.13fold higher than the wild-type value, the ratio of turnover number to KM-value for benzoylformate is 5.4fold lower than the wild-type value, the ratio of turnover number to KM-value for 2-oxohexanoic acid is 14.1fold higher than the wild-type value, the ratio of turnover number to KM-value for 2-oxopentanoic acid is 4.6fold higher than the wild-type value. Mutation has no effect on the range of products obtained by carboligation of acetaldehyde and benzaldehyde, the yield of the product 2-hydroxypropiophenone an decreases about 3fold and the enantioselectivity of acetoin and 2-hydroxypropiophenone is altered 666806
Show all pathways known for 4.1.1.7Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.7A460I for this variant the highest amounts of (S)-2-hydroxypropiophenone-product can be detected at low benzaldehyde concentrations and slightly acidic conditions at pH 6.5 702796
Show all pathways known for 4.1.1.7Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.7A460I site-directed mutagenesis, the mutant enzymes is an excellent 2-ketohexanoate decarboxylase 727483
Show all pathways known for 4.1.1.7Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.7A460I strongly decreased activity 679209
Show all pathways known for 4.1.1.7Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.7A460I the mutant exhibits an increased (R)-2-hydroxypropiophenone selectivity 715697
Show all pathways known for 4.1.1.7Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.7A460I/F464I activity with pyruvate is higher than wild-type activity, activity with 2-oxobutanoic acid is 1.8fold lower than wild-type activity, activity with 2-oxopentanoic acid is 9.2fold lower than wild-type value, activity with 2-oxohexanoic acid is 3.3fold lower than wild-type activity, activity with 3-methyl-2-oxobutanoic acid is 1.5fold lower than wild-type activity, activity with 3-methyl-2-oxopentanoic acid is 1.2fold lower than wild-type activity, activity with 2-oxo-4-methylpentanoic acid is 1.5fold lower than wild-type activity, activity with 4,4-dimethyl-2-oxopentanoic acid is 10fold lower than wild-type activity, activity with 2-oxo-4-methylhexanoic acid is 1.1fold lower than wild-type activity, activity with benzoylformate is 64.3fold lower than wild-type activity, no activity with 2-oxo-3-phenylpropanoic acid, activity with 2-oxo-4-phenylbutanoic acid is 1.3fold lower than wild-type activity, activity with 2-oxo-5-phenylpentanoic acid is fold higher than wild-type activity. the ratio of turnover number to KM-value for benzoylformate is 88.7fold lower than the wild-type value 666806
Show all pathways known for 4.1.1.7Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.7A460I/F464I for this variant the highest amounts of (S)-2-hydroxypropiophenone-product can be detected at low benzaldehyde concentrations and slightly acidic conditions at pH 6.5 702796
Show all pathways known for 4.1.1.7Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.7A460I/F464I strongly decreased activity 679209
Show all pathways known for 4.1.1.7Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.7A460I/F464I the mutant exhibits an increased (R)-2-hydroxypropiophenone selectivity 715697
Results 1 - 10 of 94 > >>