Sequence of TOMT_MOUSE
EC Number:2.1.1.6
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol
Other sequences found for EC No. 2.1.1.6
General information:
Sequence
0 MSPAIALAFL PLVVTLLVRY RHHFRLLVRT VLLRGFRDCL SGLRIEERAF SYVLTHALPG
60 DPGHILTTLD HWSSCCEYLS HMGPVKGQIL MRLVEEKAPA CVLELGTYCG YSTLLIARAL
120 PPGSRLLTVE RDSRTAAVAE KVIRLAGFDE QMVELIAGSS EEVIPRLRAQ HQLNRADLVL
180 LAHRPRYYLR DLQLLEAHAL LPHGATVLAD HVLFPGAPRF LQYTKSCGRY RCRLHHTSLP
240 DFPAIKDGIA QLTYTGPG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
747558
Ahmed Z.M.,Masmoudi S.,Kalay E.,Belyantseva I.A.,Mosrati M.A.,Collin R.W.J.,Riazuddin S.,Hmani-Aifa M.,Venselaar H.,Kawar M.N.,Tlili A.,van der Zwaag B.,Khan S.Y.,Ayadi L.,Riazuddin S.A.,Morell R.J.,Griffith A.J.,Charfedine I.,Caylan R.,Oostrik J.,Karaguzel A.,Ghorbel A.,Riazuddin S.,Friedman T.B.,Ayadi H.,Kremer H.
Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans.
Nat. Genet.
40
1335-1340
2008
747559
Du X.,Schwander M.,Moresco E.M.Y.,Viviani P.,Haller C.,Hildebrand M.S.,Pak K.,Tarantino L.,Roberts A.,Richardson H.,Koob G.,Najmabadi H.,Ryan A.F.,Smith R.J.H.,Mueller U.,Beutler B.
A catechol-O-methyltransferase that is essential for auditory function in mice and humans.
Proc. Natl. Acad. Sci. U.S.A.
105
14609-14614
2008
747560
Cunningham C.L.,Wu Z.,Jafari A.,Zhao B.,Schrode K.,Harkins-Perry S.,Lauer A.,Mueller U.
The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells.
Elife
6
0-0
2017
747561
Erickson T.,Morgan C.P.,Olt J.,Hardy K.,Busch-Nentwich E.,Maeda R.,Clemens R.,Krey J.F.,Nechiporuk A.,Barr-Gillespie P.G.,Marcotti W.,Nicolson T.
Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt).
Elife
6
0-0
2017
