Sequence of CP3A4_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
quinine 3-monooxygenase
P08684
Homo sapiens
503
57343
Reaction
quinine + [reduced NADPH-hemoprotein reductase] + O2 = 3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MALIPDLAME TWLLLAVSLV LLYLYGTHSH GLFKKLGIPG PTPLPFLGNI LSYHKGFCMF
 60 DMECHKKYGK VWGFYDGQQP VLAITDPDMI KTVLVKECYS VFTNRRPFGP VGFMKSAISI
120 AEDEEWKRLR SLLSPTFTSG KLKEMVPIIA QYGDVLVRNL RREAETGKPV TLKDVFGAYS
180 MDVITSTSFG VNIDSLNNPQ DPFVENTKKL LRFDFLDPFF LSITVFPFLI PILEVLNICV
240 FPREVTNFLR KSVKRMKESR LEDTQKHRVD FLQLMIDSQN SKETESHKAL SDLELVAQSI
300 IFIFAGYETT SSVLSFIMYE LATHPDVQQK LQEEIDAVLP NKAPPTYDTV LQMEYLDMVV
360 NETLRLFPIA MRLERVCKKD VEINGMFIPK GVVVMIPSYA LHRDPKYWTE PEKFLPERFS
420 KKNKDNIDPY IYTPFGSGPR NCIGMRFALM NMKLALIRVL QNFSFKPCKE TQIPLKLSLG
480 GLLQPEKPVV LKVESRDGTV SGA
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
759322
Molowa D.T.,Schuetz E.G.,Wrighton S.A.,Watkins P.B.,Kremers P.,Mendez-Picon G.,Parker G.A.,Guzelian P.S.
Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.
Proc. Natl. Acad. Sci. U.S.A.
83
5311-5315
1986
759323
Gonzalez F.J.,Schmid B.J.,Umeno M.,McBride O.W.,Hardwick J.P.,Meyer U.A.,Gelboin H.V.,Idle J.R.
Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.
DNA
7
79-86
1988
759324
Beaune P.H.,Umbenhauer D.R.,Bork R.W.,Lloyd R.S.,Guengerich F.P.
Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase.
Proc. Natl. Acad. Sci. U.S.A.
83
8064-8068
1986
759325
Spurr N.K.,Gough A.C.,Stevenson K.,Wolf C.R.
The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter.
Hum. Genet.
81
171-174
1989
759326
Bork R.W.,Muto T.,Beaune P.H.,Srivastava P.K.,Lloyd R.S.,Guengerich F.P.
Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity.
J. Biol. Chem.
264
910-919
1989
759327
Chen Q.,Wu J.,Yu Y.
Establishment of transgenic cell line CHL-3A4 and its metabolic activation.
Zhonghua Yu Fang Yi Xue Za Zhi
32
281-284
1998
759328
Gellner K.,Eiselt R.,Hustert E.,Arnold H.,Koch I.,Haberl M.,Deglmann C.J.,Burk O.,Buntefuss D.,Escher S.,Bishop C.,Koebe H.-G.,Brinkmann U.,Klenk H.-P.,Kleine K.,Meyer U.A.,Wojnowski L.
Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.
Pharmacogenetics
11
111-121
2001
759329
Hsieh K.-P.,Lin Y.-Y.,Cheng C.-L.,Lai M.-L.,Lin M.-S.,Siest J.-P.,Huang J.-D.
Novel mutations of CYP3A4 in Chinese.
Drug Metab. Dispos.
29
268-273
2001
759331
Komori M.,Hashizume T.,Ohi H.,Miura T.,Kitada M.,Nagashima K.,Kamataki T.
Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization.
J. Biochem.
104
912-916
1988
759332
Watkins P.B.,Wrighton S.A.,Maurel P.,Schuetz E.G.,Mendez-Picon G.,Parker G.A.,Guzelian P.S.
Identification of an inducible form of cytochrome P-450 in human liver.
Proc. Natl. Acad. Sci. U.S.A.
82
6310-6314
1985
759333
Aoyama T.,Yamano S.,Waxman D.J.,Lapenson D.P.,Meyer U.A.,Fischer V.,Tyndale R.,Inaba T.,Kalow W.,Gelboin H.V.,Gonzalez F.J.
Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.
J. Biol. Chem.
264
10388-10395
1989
759334
Shimada T.,Yamazaki H.,Mimura M.,Inui Y.,Guengerich F.P.
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
J. Pharmacol. Exp. Ther.
270
414-423
1994
759335
Kolars J.C.,Lown K.S.,Schmiedlin-Ren P.,Ghosh M.,Fang C.,Wrighton S.A.,Merion R.M.,Watkins P.B.
CYP3A gene expression in human gut epithelium.
Pharmacogenetics
4
247-259
1994
759336
Zhao X.J.,Yokoyama H.,Chiba K.,Wanwimolruk S.,Ishizaki T.
Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450.
J. Pharmacol. Exp. Ther.
279
1327-1334
1996
759337
Bylund J.,Kunz T.,Valmsen K.,Oliw E.H.
Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes.
J. Pharmacol. Exp. Ther.
284
51-60
1998
759338
Rawden H.C.,Kokwaro G.O.,Ward S.A.,Edwards G.
Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes.
Br. J. Clin. Pharmacol.
49
313-322
2000
759339
Chen H.,Howald W.N.,Juchau M.R.
Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.
Drug Metab. Dispos.
28
315-322
2000
759340
Marill J.,Cresteil T.,Lanotte M.,Chabot G.G.
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
Mol. Pharmacol.
58
1341-1348
2000
759341
Miyazawa M.,Shindo M.,Shimada T.
Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes.
Drug Metab. Dispos.
29
200-205
2001
759342
Badawi A.F.,Cavalieri E.L.,Rogan E.G.
Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol.
Metabolism
50
1001-1003
2001
759343
Miyazawa M.,Shindo M.,Shimada T.
Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes.
Xenobiotica
31
713-723
2001
759344
Finta C.,Zaphiropoulos P.G.
Intergenic mRNA molecules resulting from trans-splicing.
J. Biol. Chem.
277
5882-5890
2002
759345
Lee A.J.,Conney A.H.,Zhu B.T.
Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol.
Cancer Res.
63
6532-6536
2003
759346
Lee A.J.,Cai M.X.,Thomas P.E.,Conney A.H.,Zhu B.T.
Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.
Endocrinology
144
3382-3398
2003
759347
Krauser J.A.,Voehler M.,Tseng L.H.,Schefer A.B.,Godejohann M.,Guengerich F.P.
Testosterone 1 beta-hydroxylation by human cytochrome P450 3A4.
Eur. J. Biochem.
271
3962-3969
2004
759348
Choi M.H.,Skipper P.L.,Wishnok J.S.,Tannenbaum S.R.
Characterization of testosterone 11 beta-hydroxylation catalyzed by human liver microsomal cytochromes P450.
Drug Metab. Dispos.
33
714-718
2005
759349
Dauchy S.,Dutheil F.,Weaver R.J.,Chassoux F.,Daumas-Duport C.,Couraud P.O.,Scherrmann J.M.,De Waziers I.,Decleves X.
ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.
J. Neurochem.
107
1518-1528
2008
759350
Agarwal V.,Kommaddi R.P.,Valli K.,Ryder D.,Hyde T.M.,Kleinman J.E.,Strobel H.W.,Ravindranath V.
Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite.
PLoS ONE
3
0-0
2008
759351
Pabarcus M.K.,Hoe N.,Sadeghi S.,Patterson C.,Wiertz E.,Correia M.A.
CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases.
Arch. Biochem. Biophys.
483
66-74
2009
759352
Dutheil F.,Dauchy S.,Diry M.,Sazdovitch V.,Cloarec O.,Mellottee L.,Bieche I.,Ingelman-Sundberg M.,Flinois J.P.,de Waziers I.,Beaune P.,Decleves X.,Duyckaerts C.,Loriot M.A.
Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function.
Drug Metab. Dispos.
37
1528-1538
2009
759353
Pratt-Hyatt M.,Zhang H.,Snider N.T.,Hollenberg P.F.
Effects of a commonly occurring genetic polymorphism of human CYP3A4 (I118V) on the metabolism of anandamide.
Drug Metab. Dispos.
38
2075-2082
2010
759354
Lucas D.,Goulitquer S.,Marienhagen J.,Fer M.,Dreano Y.,Schwaneberg U.,Amet Y.,Corcos L.
Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.
J. Lipid Res.
51
1125-1133
2010
759355
Peng C.C.,Templeton I.,Thummel K.E.,Davis C.,Kunze K.L.,Isoherranen N.
Evaluation of 6beta-hydroxycortisol, 6beta-hydroxycortisone, and a combination of the two as endogenous probes for inhibition of CYP3A4 in vivo.
Clin. Pharmacol. Ther.
89
888-895
2011
759356
Honda A.,Miyazaki T.,Ikegami T.,Iwamoto J.,Maeda T.,Hirayama T.,Saito Y.,Teramoto T.,Matsuzaki Y.
Cholesterol 25-hydroxylation activity of CYP3A.
J. Lipid Res.
52
1509-1516
2011
759357
Cheng Q.,Sohl C.D.,Yoshimoto F.K.,Guengerich F.P.
Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4.
J. Biol. Chem.
287
29554-29567
2012
759358
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
759359
Yano J.K.,Wester M.R.,Schoch G.A.,Griffin K.J.,Stout C.D.,Johnson E.F.
The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution.
J. Biol. Chem.
279
38091-38094
2004
759360
Williams P.A.,Cosme J.,Vinkovic D.M.,Ward A.,Angove H.C.,Day P.J.,Vonrhein C.,Tickle I.J.,Jhoti H.
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone.
Science
305
683-686
2004
759361
Sata F.,Sapone A.,Elizondo G.,Stocker P.,Miller V.P.,Zheng W.,Raunio H.,Crespi C.L.,Gonzalez F.J.
CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity.
Clin. Pharmacol. Ther.
67
48-56
2000
759362
Dai D.,Tang J.,Rose R.,Hodgson E.,Bienstock R.J.,Mohrenweiser H.W.,Goldstein J.A.
Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos.
J. Pharmacol. Exp. Ther.
299
825-831
2001
759363
Eiselt R.,Domanski T.L.,Zibat A.,Mueller R.,Presecan-Siedel E.,Hustert E.,Zanger U.M.,Brockmoller J.,Klenk H.-P.,Meyer U.A.,Khan K.K.,He Y.-A.,Halpert J.R.,Wojnowski L.
Identification and functional characterization of eight CYP3A4 protein variants.
Pharmacogenetics
11
447-458
2001
759364
Lamba J.K.,Lin Y.S.,Thummel K.,Daly A.,Watkins P.B.,Strom S.,Zhang J.,Schuetz E.G.
Common allelic variants of cytochrome P4503A4 and their prevalence in different populations.
Pharmacogenetics
12
121-132
2002
759365
Solus J.F.,Arietta B.J.,Harris J.R.,Sexton D.P.,Steward J.Q.,McMunn C.,Ihrie P.,Mehall J.M.,Edwards T.L.,Dawson E.P.
Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.
Pharmacogenomics
5
895-931
2004