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Sequence of PLPP3_HUMAN

EC Number:3.1.3.4

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
phosphatidate phosphatase
O14495
Homo sapiens
311
35116
Reaction
a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate
Other sequences found for EC No. 3.1.3.4

General information:

Sequence
show sequence in fasta format
  0 MQNYKYDKAI VPESKNGGSP ALNNNPRRSG SKRVLLICLD LFCLFMAGLP FLIIETSTIK
 60 PYHRGFYCND ESIKYPLKTG ETINDAVLCA VGIVIAILAI ITGEFYRIYY LKKSRSTIQN
120 PYVAALYKQV GCFLFGCAIS QSFTDIAKVS IGRLRPHFLS VCNPDFSQIN CSEGYIQNYR
180 CRGDDSKVQE ARKSFFSGHA SFSMYTMLYL VLYLQARFTW RGARLLRPLL QFTLIMMAFY
240 TGLSRVSDHK HHPSDVLAGF AQGALVACCI VFFVSDLFKT KTTLSLPAPA IRKEILSPVD
300 IIDRNNHHNM M
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
841489
Kai M.,Wada I.,Imai S.,Sakane F.,Kanoh H.
Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase.
J. Biol. Chem.
272
24572-24578
1997
841490
Roberts R.,Sciorra V.A.,Morris A.J.
Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.
J. Biol. Chem.
273
22059-22067
1998
841491
Humtsoe J.O.,Feng S.,Thakker G.D.,Yang J.,Hong J.,Wary K.K.
Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP.
EMBO J.
22
1539-1554
2003
841493
Yu W.,Andersson B.,Worley K.C.,Muzny D.M.,Ding Y.,Liu W.,Ricafrente J.Y.,Wentland M.A.,Lennon G.,Gibbs R.A.
Large-scale concatenation cDNA sequencing.
Genome Res.
7
353-358
1997
841494
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
841497
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
841498
Hooks S.B.,Ragan S.P.,Lynch K.R.
Identification of a novel human phosphatidic acid phosphatase type 2 isoform.
FEBS Lett.
427
188-192
1998
841499
Jia Y.J.,Kai M.,Wada I.,Sakane F.,Kanoh H.
Differential localization of lipid phosphate phosphatases 1 and 3 to cell surface subdomains in polarized MDCK cells.
FEBS Lett.
552
240-246
2003
841500
Burnett C.,Makridou P.,Hewlett L.,Howard K.
Lipid phosphate phosphatases dimerise, but this interaction is not required for in vivo activity.
BMC Biochem.
5
2-2
2004
841501
Humtsoe J.O.,Bowling R.A. Jr.,Feng S.,Wary K.K.
Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand.
Biochem. Biophys. Res. Commun.
335
906-919
2005
841502
Kai M.,Sakane F.,Jia Y.J.,Imai S.,Yasuda S.,Kanoh H.
Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts.
J. Biochem.
140
677-686
2006
841503
Long J.S.,Pyne N.J.,Pyne S.
Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function.
Biochem. J.
411
371-377
2008
841504
Daub H.,Olsen J.V.,Bairlein M.,Gnad F.,Oppermann F.S.,Korner R.,Greff Z.,Keri G.,Stemmann O.,Mann M.
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Mol. Cell
31
438-448
2008
841505
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
841506
Humtsoe J.O.,Liu M.,Malik A.B.,Wary K.K.
Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures.
Mol. Cell. Biol.
30
1593-1606
2010
841507
Chatterjee I.,Humtsoe J.O.,Kohler E.E.,Sorio C.,Wary K.K.
Lipid phosphate phosphatase-3 regulates tumor growth via beta-catenin and CYCLIN-D1 signaling.
Mol. Cancer
10
51-51
2011
841508
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
841509
Gutierrez-Martinez E.,Fernandez-Ulibarri I.,Lazaro-Dieguez F.,Johannes L.,Pyne S.,Sarri E.,Egea G.
Lipid phosphate phosphatase 3 participates in transport carrier formation and protein trafficking in the early secretory pathway.
J. Cell Sci.
126
2641-2655
2013
841510
Touat-Hamici Z.,Weidmann H.,Blum Y.,Proust C.,Durand H.,Iannacci F.,Codoni V.,Gaignard P.,Therond P.,Civelek M.,Karabina S.A.,Lusis A.J.,Cambien F.,Ninio E.
Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function.
Cardiovasc. Res.
112
702-713
2016