Sequence of AT8A2_BOVIN
EC Number:7.6.2.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2]
Other sequences found for EC No. 7.6.2.1
General information:
Sequence
0 MSRATSVGDQ LDVPARTIYL NQPHLNKFCD NQISTAKYSV VTFLPRFLYE QIRRAANAFF
60 LFIALLQQIP DVSPTGRYTT LVPLIIILTI AGIKEIVEDF KRHKADNAVN KKKTIVLRNG
120 MWQTIVWKEV AVGDIVKVVN GQYLPADVVL LSSSEPQAMC YVETANLDGE TNLKIRQGLS
180 HTADMQTREV LMKLSGTIEC EGPNRHLYDF TGNLNLDGKS PVALGPDQIL LRGTQLRNTQ
240 WGFGIVVYTG HDTKLMQNST KAPLKRSNVE KVTNVQILVL FGILLVMALV SSVGALYWNG
300 SQGGKNWYIK KMDATSDNFG YNLLTFIILY NNLIPISLLV TLEVVKYTQA LFINWDTDMY
360 YLGNDTPAMA RTSNLNEELG QVKYLFSDKT GTLTCNIMNF KKCSIAGVTY GHFPELTREP
420 SSDDFSRIPP PPSDSCDFDD PRLLKNIEDH HPTAPCIQEF LTLLAVCHTV VPERDGDSIV
480 YQASSPDEAA LVKGARKLGF VFTARTPYSV IIEAMGQEQT FGILNVLEFS SDRKRMSVIV
540 RTPSGQLRLY CKGADNVIFE RLSKDSKYME ETLCHLEYFA TEGLRTLCVA YADLSERDYE
600 EWLKVYQEAS TILKDRAQRL EECYEIIEKN LLLLGATAIE DRLQAGVPET IATLLKAEIK
660 IWVLTGDKQE TAINIGYSCR LVSQNMALIL LKEDSLDATR AAITQHCADL GSLLGKENDA
720 ALIIDGHTLK YALSFEVRRS FLDLALSCKA VICCRVSPLQ KSEIVDVVKK RVKAITLAIG
780 DGANDVGMIQ TAHVGVGISG NEGMQATNNS DYAIAQFSYL EKLLLVHGAW SYNRVTKCIL
840 YCFYKNVVLY IIELWFAFVN GFSGQILFER WCIGLYNVIF TALPPFTLGI FERSCSQESM
900 LRFPQLYKIT QNAEGFNTKV FWGHCINALV HSLILFWFPM KALEHDTVLA NGHATDYLFV
960 GNIVYTYVVV TVCLKAGLET TAWTKFSHLA VWGSMLIWLV FFGIYSTIWP TIPIAPDMKG
1020 QATMVLSSAH FWLGLFLVPT ACLIEDVAWR AAKHTCKKTL LEEVQELEMK SRVMGRAMLR
1080 DSNGKRMNER DRLLKRLSRK TPPTLFRGSS LQQSMPHGYA FSQEEHGAVT QEEIVRAYDT
1140 TKQKSRKK
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
7788
Coleman J.A.,Kwok M.C.,Molday R.S.
Localization, purification, and functional reconstitution of the P4-ATPase Atp8a2, a phosphatidylserine flippase in photoreceptor disc membranes.
J. Biol. Chem.
284
32670-32679
2009
7789
Coleman J.A.,Molday R.S.
Critical role of the beta-subunit CDC50A in the stable expression, assembly, subcellular localization, and lipid transport activity of the P4-ATPase ATP8A2.
J. Biol. Chem.
286
17205-17216
2011
7790
Coleman J.A.,Vestergaard A.L.,Molday R.S.,Vilsen B.,Andersen J.P.
Critical role of a transmembrane lysine in aminophospholipid transport by mammalian photoreceptor P4-ATPase ATP8A2.
Proc. Natl. Acad. Sci. U.S.A.
109
1449-1454
2012
7791
Vestergaard A.L.,Coleman J.A.,Lemmin T.,Mikkelsen S.A.,Molday L.L.,Vilsen B.,Molday R.S.,Dal Peraro M.,Andersen J.P.
Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2.
Proc. Natl. Acad. Sci. U.S.A.
111
0-0
2014
7792
Vestergaard A.L.,Mikkelsen S.A.,Coleman J.A.,Molday R.S.,Vilsen B.,Andersen J.P.
Specific mutations in mammalian P4-ATPase ATP8A2 catalytic subunit entail differential glycosylation of the accessory CDC50A subunit.
FEBS Lett.
589
3908-3914
2015
7793
Tadini-Buoninsegni F.,Mikkelsen S.A.,Mogensen L.S.,Molday R.S.,Andersen J.P.
Phosphatidylserine flipping by the P4-ATPase ATP8A2 is electrogenic.
Proc. Natl. Acad. Sci. U.S.A.
116
16332-16337
2019
