Sequence of B4GT1_BOVIN
EC Number:2.4.1.90
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
UDP-alpha-D-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine
Other sequences found for EC No. 2.4.1.90
General information:
Sequence
0 MKFREPLLGG SAAMPGASLQ RACRLLVAVC ALHLGVTLVY YLAGRDLRRL PQLVGVHPPL
60 QGSSHGAAAI GQPSGELRLR GVAPPPPLQN SSKPRSRAPS NLDAYSHPGP GPGPGSNLTS
120 APVPSTTTRS LTACPEESPL LVGPMLIEFN IPVDLKLVEQ QNPKVKLGGR YTPMDCISPH
180 KVAIIIPFRN RQEHLKYWLY YLHPILQRQQ LDYGIYVINQ AGESMFNRAK LLNVGFKEAL
240 KDYDYNCFVF SDVDLIPMND HNTYRCFSQP RHISVAMDKF GFSLPYVQYF GGVSALSKQQ
300 FLSINGFPNN YWGWGGEDDD IYNRLAFRGM SVSRPNAVIG KCRMIRHSRD KKNEPNPQRF
360 DRIAHTKETM LSDGLNSLTY MVLEVQRYPL YTKITVDIGT PS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
9609
D'Agostaro G.,Bendiak B.,Tropak M.
Cloning of cDNA encoding the membrane-bound form of bovine beta 1,4-galactosyltransferase.
Eur. J. Biochem.
183
211-217
1989
9611
Shaper N.L.,Shaper J.H.,Meuth J.L.,Fox J.L.,Chang H.,Kirsch I.R.,Hollis G.F.
Bovine galactosyltransferase: identification of a clone by direct immunological screening of a cDNA expression library.
Proc. Natl. Acad. Sci. U.S.A.
83
1573-1577
1986
9612
Narimatsu H.,Sinha S.,Brew K.,Okayama H.,Qasba P.K.
Cloning and sequencing of cDNA of bovine N-acetylglucosamine (beta 1-4)galactosyltransferase.
Proc. Natl. Acad. Sci. U.S.A.
83
4720-4724
1986
9614
Masibay A.S.,Qasba P.K.
Expression of bovine beta-1,4-galactosyltransferase cDNA in COS-7 cells.
Proc. Natl. Acad. Sci. U.S.A.
86
5733-5737
1989
9615
Russo R.N.,Shaper N.L.,Shaper J.H.
Bovine beta 1-->4-galactosyltransferase: two sets of mRNA transcripts encode two forms of the protein with different amino-terminal domains. In vitro translation experiments demonstrate that both the short and the long forms of the enzyme are type II membrane-bound glycoproteins.
J. Biol. Chem.
265
3324-3331
1990
9616
Yadav S.P.,Brew K.
Identification of a region of UDP-galactose:N-acetylglucosamine beta 4-galactosyltransferase involved in UDP-galactose binding by differential labeling.
J. Biol. Chem.
265
14163-14169
1990
9617
Yadav S.P.,Brew K.
Structure and function in galactosyltransferase. Sequence locations of alpha-lactalbumin binding site, thiol groups, and disulfide bond.
J. Biol. Chem.
266
698-703
1991
9618
Almeida R.,Amado M.,David L.,Levery S.B.,Holmes E.H.,Merkx G.,van Kessel A.G.,Rygaard E.,Hassan H.,Bennett E.,Clausen H.
A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3.
J. Biol. Chem.
272
31979-31991
1997
9619
Gastinel L.N.,Cambillau C.,Bourne Y.
Crystal structures of the bovine beta4galactosyltransferase catalytic domain and its complex with uridine diphosphogalactose.
EMBO J.
18
3546-3557
1999
9620
Ramakrishnan B.,Qasba P.K.
Crystal structure of lactose synthase reveals a large conformational change in its catalytic component, the beta1,4-galactosyltransferase-I.
J. Mol. Biol.
310
205-218
2001
9621
Ramakrishnan B.,Balaji P.V.,Qasba P.K.
Crystal structure of beta1,4-galactosyltransferase complex with UDP-Gal reveals an oligosaccharide acceptor binding site.
J. Mol. Biol.
318
491-502
2002
9622
Ramasamy V.,Ramakrishnan B.,Boeggeman E.,Qasba P.K.
The role of tryptophan 314 in the conformational changes of beta1,4-galactosyltransferase-I.
J. Mol. Biol.
331
1065-1076
2003
