Sequence of A4HSF7_LEIIN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
trypanothione-disulfide reductase
A4HSF7
Leishmania infantum
491
53026
Reaction
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MSRAYDLVVL GAGSGGLEAG WNAAVTHKKK VAVVDVQATH GPPLFAALGG TCVNVGCVPK
 60 KLMVTGAQYM DLIRESGGFG WEMDRESLCP NWKTLIAAKN KVVNSINESY KSMFADTEGL
120 SFHMGFGALQ DAHTVVVRKS EDPHSDVLET LDTEYILIAT GSWPTRLGVP GDEFCITSNE
180 AFYLEDAPKR MLCVGGGYIA VEFAGIFNGY KPCGGYVDLC YRGDLILRGF DTEVRKSLTK
240 QLGANGIRVR TNLNPTKITK NEDGSNHVHF NDGTEEDYDQ VMLAIGRVPR SQALQLDKAG
300 VRTGKNGAVQ VDAYSKTSVD NIYAIGDVTN RVMLTPVAIN EGAAFVETVF GGKPRATDHT
360 KVACAVFSIP PIGTCGMTEE EAAKNYETVA VYASSFTPLM HNISGSKHKE FMIRIITNES
420 NGEVLGVHML GDSAPEIIQS VGICMKMGAK ISDFHSTIGV HPTSAEELCS MRTPAYFYES
480 GKRVEKLSSN L
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
29011514
Peacock C.S.,Seeger K.,Harris D.,Murphy L.,Ruiz J.C.,Quail M.A.,Peters N.,Adlem E.,Tivey A.,Aslett M.,Kerhornou A.,Ivens A.,Fraser A.,Rajandream M.-A.,Carver T.,Norbertczak H.,Chillingworth T.,Hance Z.,Jagels K.,Moule S.,Ormond D.,Rutter S.,Sqaures R.,Whitehead S.,Rabbinowitsch E.,Arrowsmith C.,White B.,Thurston S.,Bringaud F.,Baldauf S.L.,Faulconbridge A.,Jeffares D.,Depledge D.P.,Oyola S.O.,Hilley J.D.,Brito L.O.,Tosi L.R.O.,Barrell B.,Cruz A.K.,Mottram J.C.,Smith D.F.,Berriman M.
Comparative genomic analysis of three Leishmania species that cause diverse human disease.
Nat. Genet.
39
839-847
2007
29011515
Baiocco P.,Colotti G.,Franceschini S.,Ilari A.
Molecular basis of antimony treatment in leishmaniasis.
J. Med. Chem.
52
2603-2612
2009
29011516
Baiocco P.,Ilari A.,Ceci P.,Orsini S.,Gramiccia M.,Di Muccio T.,Colotti G.
Inhibitory Effect of Silver Nanoparticles on Trypanothione Reductase Activity and Leishmania infantum Proliferation.
ACS Med. Chem. Lett.
2
230-233
2011
29011517
Rogers M.B.,Hilley J.D.,Dickens N.J.,Wilkes J.,Bates P.A.,Depledge D.P.,Harris D.,Her Y.,Herzyk P.,Imamura H.,Otto T.D.,Sanders M.,Seeger K.,Dujardin J.C.,Berriman M.,Smith D.F.,Hertz-Fowler C.,Mottram J.C.
Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania.
Genome Res.
21
2129-2142
2011
29011519
Ilari A.,Baiocco P.,Messori L.,Fiorillo A.,Boffi A.,Gramiccia M.,Di Muccio T.,Colotti G.
A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition.
Amino Acids
42
803-811
2012
29011520
Baiocco P.,Poce G.,Alfonso S.,Cocozza M.,Porretta G.C.,Colotti G.,Biava M.,Moraca F.,Botta M.,Yardley V.,Fiorillo A.,Lantella A.,Malatesta F.,Ilari A.
Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography.
ChemMedChem
8
1175-1183
2013
29011521
Saccoliti F.,Angiulli G.,Pupo G.,Pescatori L.,Madia V.N.,Messore A.,Colotti G.,Fiorillo A.,Scipione L.,Gramiccia M.,Di Muccio T.,Di Santo R.,Costi R.,Ilari A.
Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives.
J. Enzym. Inhib. Med. Chem.
32
304-310
2017
29011522
Turcano L.,Torrente E.,Missineo A.,Andreini M.,Gramiccia M.,Di Muccio T.,Genovese I.,Fiorillo A.,Harper S.,Bresciani A.,Colotti G.,Ilari A.
Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening.
PLoS Negl. Trop. Dis.
12
0-0
2018
29011524
Revuelto A.,Ruiz-Santaquiteria M.,de Lucio H.,Gamo A.,Carriles A.A.,Gutierrez K.J.,Sanchez-Murcia P.A.,Hermoso J.A.,Gago F.,Camarasa M.J.,Jimenez-Ruiz A.,Velazquez S.
Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase.
ACS Infect. Dis.
5
873-891
2019