Sequence of CP2C8_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
unspecific monooxygenase
P10632
Homo sapiens
490
55825
Reaction
RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MEPFVVLVLC LSFMLLFSLW RQSCRRRKLP PGPTPLPIIG NMLQIDVKDI CKSFTNFSKV
 60 YGPVFTVYFG MNPIVVFHGY EAVKEALIDN GEEFSGRGNS PISQRITKGL GIISSNGKRW
120 KEIRRFSLTT LRNFGMGKRS IEDRVQEEAH CLVEELRKTK ASPCDPTFIL GCAPCNVICS
180 VVFQKRFDYK DQNFLTLMKR FNENFRILNS PWIQVCNNFP LLIDCFPGTH NKVLKNVALT
240 RSYIREKVKE HQASLDVNNP RDFIDCFLIK MEQEKDNQKS EFNIENLVGT VADLFVAGTE
300 TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA VVHEIQRYSD
360 LVPTGVPHAV TTDTKFRNYL IPKGTTIMAL LTSVLHDDKE FPNPNIFDPG HFLDKNGNFK
420 KSDYFMPFSA GKRICAGEGL ARMELFLFLT TILQNFNLKS VDDLKNLNTT AVTKGIVSLP
480 PSYQICFIPV
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
18604
Okino S.T.,Quattrochi L.C.,Pendurthi U.R.,McBride O.W.,Tukey R.H.
Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing.
J. Biol. Chem.
262
16072-16079
1987
18605
Kimura S.,Pastewka J.,Gelboin H.V.,Gonzalez F.J.
cDNA and amino acid sequences of two members of the human P450IIC gene subfamily.
Nucleic Acids Res.
15
10053-10054
1987
18606
Romkes M.,Faletto M.B.,Blaisdell J.A.,Raucy J.L.,Goldstein J.A.
Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.
Biochemistry
30
3247-3255
1991
18607
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
18609
Deloukas P.,Earthrowl M.E.,Grafham D.V.,Rubenfield M.,French L.,Steward C.A.,Sims S.K.,Jones M.C.,Searle S.,Scott C.,Howe K.,Hunt S.E.,Andrews T.D.,Gilbert J.G.R.,Swarbreck D.,Ashurst J.L.,Taylor A.,Battles J.,Bird C.P.,Ainscough R.,Almeida J.P.,Ashwell R.I.S.,Ambrose K.D.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Bates K.,Beasley H.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Cahill P.,Camire D.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Corby N.,Coulson A.,Dhami P.,Dutta I.,Dunn M.,Faulkner L.,Frankish A.,Frankland J.A.,Garner P.,Garnett J.,Gribble S.,Griffiths C.,Grocock R.,Gustafson E.,Hammond S.,Harley J.L.,Hart E.,Heath P.D.,Ho T.P.,Hopkins B.,Horne J.,Howden P.J.,Huckle E.,Hynds C.,Johnson C.,Johnson D.,Kana A.,Kay M.,Kimberley A.M.,Kershaw J.K.,Kokkinaki M.,Laird G.K.,Lawlor S.,Lee H.M.,Leongamornlert D.A.,Laird G.,Lloyd C.,Lloyd D.M.,Loveland J.,Lovell J.,McLaren S.,McLay K.E.,McMurray A.,Mashreghi-Mohammadi M.,Matthews L.,Milne S.,Nickerson T.,Nguyen M.,Overton-Larty E.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.,Rice C.M.,Rogosin A.,Ross M.T.,Sarafidou T.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Standring L.,Sycamore N.,Tester J.,Thorpe A.,Torcasso W.,Tracey A.,Tromans A.,Tsolas J.,Wall M.,Walsh J.,Wang H.,Weinstock K.,West A.P.,Willey D.L.,Whitehead S.L.,Wilming L.,Wray P.W.,Young L.,Chen Y.,Lovering R.C.,Moschonas N.K.,Siebert R.,Fechtel K.,Bentley D.,Durbin R.M.,Hubbard T.,Doucette-Stamm L.,Beck S.,Smith D.R.,Rogers J.
The DNA sequence and comparative analysis of human chromosome 10.
Nature
429
375-381
2004
18611
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
18612
Ged C.,Beaune P.
Isolation of the human cytochrome P-450 IIC8 gene: multiple glucocorticoid responsive elements in the 5' region.
Biochim. Biophys. Acta
1088
433-435
1991
18613
Zeldin D.C.,DuBois R.N.,Falck J.R.,Capdevila J.H.
Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform.
Arch. Biochem. Biophys.
322
76-86
1995
18614
Ged C.,Umbenhauer D.R.,Bellew T.M.,Bork R.W.,Srivastava P.K.,Shinriki N.,Lloyd R.S.,Guengerich F.P.
Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase.
Biochemistry
27
6929-6940
1988
18615
Shephard E.A.,Phillips I.R.,Santisteban I.,Palmer C.N.,Povey S.
Cloning, expression and chromosomal localization of a member of the human cytochrome P450IIC gene sub-family.
Ann. Hum. Genet.
53
23-31
1989
18616
Kolyada A.Y.
Sequence of a human liver cytochrome P-450 cDNA clone.
Nucleic Acids Res.
18
5550-5550
1990
18617
Ishikawa C.,Ozaki H.,Nakajima T.,Ishii T.,Kanai S.,Anjo S.,Shirai K.,Inoue I.
A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin.
J. Hum. Genet.
49
582-585
2004
18618
Marill J.,Cresteil T.,Lanotte M.,Chabot G.G.
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
Mol. Pharmacol.
58
1341-1348
2000
18619
Lee A.J.,Conney A.H.,Zhu B.T.
Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol.
Cancer Res.
63
6532-6536
2003
18620
Barbosa-Sicard E.,Markovic M.,Honeck H.,Christ B.,Muller D.N.,Schunck W.H.
Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily.
Biochem. Biophys. Res. Commun.
329
1275-1281
2005
18621
Lucas D.,Goulitquer S.,Marienhagen J.,Fer M.,Dreano Y.,Schwaneberg U.,Amet Y.,Corcos L.
Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.
J. Lipid Res.
51
1125-1133
2010
18622
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
18623
Schoch G.A.,Yano J.K.,Wester M.R.,Griffin K.J.,Stout C.D.,Johnson E.F.
Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site.
J. Biol. Chem.
279
9497-9503
2004
18624
Schoch G.A.,Yano J.K.,Sansen S.,Dansette P.M.,Stout C.D.,Johnson E.F.
Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.
J. Biol. Chem.
283
17227-17237
2008
18625
Dai D.,Zeldin D.C.,Blaisdell J.A.,Chanas B.,Coulter S.J.,Ghanayem B.I.,Goldstein J.A.
Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.
Pharmacogenetics
11
597-607
2001
18626
Bahadur N.,Leathart J.B.,Mutch E.,Steimel-Crespi D.,Dunn S.A.,Gilissen R.,Houdt J.V.,Hendrickx J.,Mannens G.,Bohets H.,Williams F.M.,Armstrong M.,Crespi C.L.,Daly A.K.
CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes.
Biochem. Pharmacol.
64
1579-1589
2002
18627
Solus J.F.,Arietta B.J.,Harris J.R.,Sexton D.P.,Steward J.Q.,McMunn C.,Ihrie P.,Mehall J.M.,Edwards T.L.,Dawson E.P.
Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.
Pharmacogenomics
5
895-931
2004
18628
Tsukada C.,Saito T.,Maekawa M.,Mano N.,Oda A.,Hirasawa N.,Hiratsuka M.
Functional characterization of 12 allelic variants of CYP2C8 by assessment of paclitaxel 6alpha-hydroxylation and amodiaquine N-deethylation.
Drug Metab. Pharmacokinet.
30
366-373
2015