Sequence of CP51A_RAT

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
sterol 14alpha-demethylase
Q64654
Rattus norvegicus
503
56707
Reaction
a 14alpha-formylsteroid + [reduced NADPH-hemoprotein reductase] + O2 = a DELTA14-steroid + formate + [oxidized NADPH-hemoprotein reductase] + H2O
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MVLLGLLQSG GSVLGQAMEQ VTGGNLLSTL LIACAFTLSL VYLFRLAVGH MVQLPAGAKS
 60 PPYIYSPIPF LGHAIAFGKS PIEFLENAYE KYGPVFSFTM VGKTFTYLLG SDAAALLFNS
120 KNEDLNAEEV YGRLTTPVFG KGVAYDVPNA VFLEQKKILK SGLNIAHFKQ YVSIIEKEAK
180 EYFKSWGESG ERNVFEALSE LIILTASHCL HGKEIRSQLN EKVAQLYADL DGGFSHAAWL
240 LPGWLPLPSF RRRDRAHREI KNIFYKAIQK RRLSKEPAED ILQTLLDSTY KDGRPLTDDE
300 IAGMLIGLLL AGQHTSSTTS AWMGFFLARD KPLQDKCYLE QKTVCGEDLP PLTYEQLKDL
360 NLLDRCIKET LRLRPPIMTM MRMAKTPQTV AGYTIPPGHQ VCVSPTVNQR LKDSWVERLD
420 FNPDRYLQDN PASGEKFAYV PFGAGRHRCI GENFAYVQIK TIWSTMLRLY EFDLINGYFP
480 SVNYTTMIHT PENPVIRYKR RSK
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
18771
Aoyama Y.,Funae Y.,Noshiro M.,Horiuchi T.,Yoshida Y.
Occurrence of a P450 showing high homology to yeast lanosterol 14-demethylase (P450(14DM)) in the rat liver.
Biochem. Biophys. Res. Commun.
201
1320-1326
1994
18772
Noshiro M.,Aoyama Y.,Kawamoto T.,Gotoh O.,Horiuchi T.,Yoshida Y.
Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: I. Structural analyses of the gene and multiple sizes of mRNA.
J. Biochem.
122
1114-1121
1997
18773
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
18774
Sloane D.L.,So O.Y.,Leung R.,Scarafia L.E.,Saldou N.,Jarnagin K.,Swinney D.C.
Cloning and functional expression of the cDNA encoding rat lanosterol 14-alpha demethylase.
Gene
161
243-248
1995
18775
Aoyama Y.,Noshiro M.,Gotoh O.,Imaoka S.,Funae Y.,Kurosawa N.,Horiuchi T.,Yoshida Y.
Sterol 14-demethylase P450 (P45014DM*) is one of the most ancient and conserved P450 species.
J. Biochem.
119
926-933
1996