Sequence of MASP2_RAT

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
mannan-binding lectin-associated serine protease-2
Q9JJS8
Rattus norvegicus
685
75667
Reaction
Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-/-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-/-Ala-Leu-Glu-Ile)
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MRLLIVLGLL WSLVATLLGS KWPEPVFGRL VSLGFPEKYG NHQDRSWTLT APPGFRLRLY
 60 FTHFNLELSY RCEYDFVKLT SGTKVLATLC GQESTDTERA PGNDTFYSLG PSLKVTFHSD
120 YSNEKPFTGF EAFYAAEDVD ECRTSLGDSV PCDHYCHNYL GGYYCSCRVG YILHQNKHTC
180 SALCSGQVFT GRSGFLSSPE YPQPYPKLSS CAYNIRLEEG FSITLDFVES FDVEMHPEAQ
240 CPYDSLKIQT DKREYGPFCG KTLPPRIETD SNKVTITFTT DESGNHTGWK IHYTSTAQPC
300 PDPTAPPNGH ISPVQATYVL KDSFSVFCKT GFELLQGSVP LKSFTAVCQK DGSWDRPIPE
360 CSIIDCGPPD DLPNGHVDYI TGPEVTTYKA VIQYSCEETF YTMSSNGKYV CEADGFWTSS
420 KGEKSLPVCK PVCGLSTHTS GGRIIGGQPA KPGDFPWQVL LLGETTAAGA LIHDDWVLTA
480 AHAVYGKTEA MSSLDIRMGI LKRLSLIYTQ AWPEAVFIHE GYTHGAGFDN DIALIKLKNK
540 VTINRNIMPI CLPRKEAASL MKTDFVGTVA GWGLTQKGFL ARNLMFVDIP IVDHQKCATA
600 YTKQPYPGAK VTVNMLCAGL DRGGKDSCRG DSGGALVFLD NETQRWFVGG IVSWGSINCG
660 GSEQYGVYTK VTNYIPWIEN IINNF
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
179124
Stover C.M.,Thiel S.,Lynch N.J.,Schwaeble W.J.
The rat and mouse homologues of MASP-2 and MAp19, components of the mannan-binding lectin activation pathway of complement.
J. Immunol.
163
6848-6859
1999
179125
Stover C.M.,Lynch N.J.,Hanson S.J.,Windbichler M.,Gregory S.G.,Schwaeble W.J.
Organization of the MASP2 locus and its expression profile in mouse and rat.
Mamm. Genome
15
887-900
2004
179126
Wallis R.,Dodd R.B.
Interaction of mannose-binding protein with associated serine proteases: effects of naturally occurring mutations.
J. Biol. Chem.
275
30962-30969
2000
179127
Stover C.M.,Thiel S.,Thelen M.,Lynch N.J.,Vorup-Jensen T.,Jensenius J.C.,Schwaeble W.J.
Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene.
J. Immunol.
162
3481-3490
1999
179128
Feinberg H.,Uitdehaag J.C.M.,Davies J.M.,Wallis R.,Drickamer K.,Weis W.I.
Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2.
EMBO J.
22
2348-2359
2003