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Sequence of PARP2_HUMAN

EC Number:2.4.2.30

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
NAD+ ADP-ribosyltransferase
Q9UGN5
Homo sapiens
583
66206
Reaction
NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
Other sequences found for EC No. 2.4.2.30

General information:

Sequence
show sequence in fasta format
  0 MAARRRRSTG GGRARALNES KRVNNGNTAP EDSSPAKKTR RCQRQESKKM PVAGGKANKD
 60 RTEDKQDGMP GRSWASKRVS ESVKALLLKG KAPVDPECTA KVGKAHVYCE GNDVYDVMLN
120 QTNLQFNNNK YYLIQLLEDD AQRNFSVWMR WGRVGKMGQH SLVACSGNLN KAKEIFQKKF
180 LDKTKNNWED REKFEKVPGK YDMLQMDYAT NTQDEEETKK EESLKSPLKP ESQLDLRVQE
240 LIKLICNVQA MEEMMMEMKY NTKKAPLGKL TVAQIKAGYQ SLKKIEDCIR AGQHGRALME
300 ACNEFYTRIP HDFGLRTPPL IRTQKELSEK IQLLEALGDI EIAIKLVKTE LQSPEHPLDQ
360 HYRNLHCALR PLDHESYEFK VISQYLQSTH APTHSDYTMT LLDLFEVEKD GEKEAFREDL
420 HNRMLLWHGS RMSNWVGILS HGLRIAPPEA PITGYMFGKG IYFADMSSKS ANYCFASRLK
480 NTGLLLLSEV ALGQCNELLE ANPKAEGLLQ GKHSTKGLGK MAPSSAHFVT LNGSTVPLGP
540 ASDTGILNPD GYTLNYNEYI VYNPNQVRMR YLLKVQFNFL QLW
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
201922
Ame J.-C.,Rolli V.,Schreiber V.,Niedergang C.,Apiou F.,Decker P.,Muller S.,Hoeger T.,Menissier-de Murcia J.,de Murcia G.M.
PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase.
J. Biol. Chem.
274
17860-17868
1999
201923
Johansson M.
A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues.
Genomics
57
442-445
1999
201924
Berghammer H.,Ebner M.,Marksteiner R.,Auer B.
pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans.
FEBS Lett.
449
259-263
1999
201925
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
201927
Schreiber V.,Ame J.-C.,Dolle P.,Schultz I.,Rinaldi B.,Fraulob V.,Menissier-de Murcia J.,de Murcia G.M.
Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1.
J. Biol. Chem.
277
23028-23036
2002
201928
Hottiger M.O.,Hassa P.O.,Luscher B.,Schuler H.,Koch-Nolte F.
Toward a unified nomenclature for mammalian ADP-ribosyltransferases.
Trends Biochem. Sci.
35
208-219
2010
201929
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
201930
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
201931
Gibbs-Seymour I.,Fontana P.,Rack J.G.,Ahel I.
HPF1/C4orf27 is a PARP-1-interacting protein that regulates PARP-1 ADP-ribosylation activity.
Mol. Cell
62
432-442
2016
201932
Bonfiglio J.J.,Fontana P.,Zhang Q.,Colby T.,Gibbs-Seymour I.,Atanassov I.,Bartlett E.,Zaja R.,Ahel I.,Matic I.
Serine ADP-ribosylation depends on HPF1.
Mol. Cell
0
0-0
2017
201933
Vyas S.,Matic I.,Uchima L.,Rood J.,Zaja R.,Hay R.T.,Ahel I.,Chang P.
Family-wide analysis of poly(ADP-ribose) polymerase activity.
Nat. Commun.
5
4426-4426
2014
201934
Talhaoui I.,Lebedeva N.A.,Zarkovic G.,Saint-Pierre C.,Kutuzov M.M.,Sukhanova M.V.,Matkarimov B.T.,Gasparutto D.,Saparbaev M.K.,Lavrik O.I.,Ishchenko A.A.
Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro.
Nucleic Acids Res.
44
9279-9295
2016
201935
Karlberg T.,Hammarstrom M.,Schutz P.,Svensson L.,Schuler H.
Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.
Biochemistry
49
1056-1058
2010
201936
Riccio A.A.,Cingolani G.,Pascal J.M.
PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage.
Nucleic Acids Res.
44
1691-1702
2016
201937
Obaji E.,Haikarainen T.,Lehtioe L.
Structural basis for DNA break recognition by ARTD2/PARP2.
Nucleic Acids Res.
46
12154-12165
2018
201938
Suskiewicz M.J.,Zobel F.,Ogden T.E.H.,Fontana P.,Ariza A.,Yang J.C.,Zhu K.,Bracken L.,Hawthorne W.J.,Ahel D.,Neuhaus D.,Ahel I.
HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.
Nature
579
598-602
2020
201939
Bilokapic S.,Suskiewicz M.J.,Ahel I.,Halic M.
Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin.
Nature
585
609-613
2020
201940
Gaullier G.,Roberts G.,Muthurajan U.M.,Bowerman S.,Rudolph J.,Mahadevan J.,Jha A.,Rae P.S.,Luger K.
Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1.
PLoS ONE
15
0-0
2020