Sequence of PARP2_MOUSE
EC Number:2.4.2.30
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
Other sequences found for EC No. 2.4.2.30
General information:
Sequence
0 MAPRRQRSGS GRRVLNEAKK VDNGNKATED DSPPGKKMRT CQRKGPMAGG KDADRTKDNR
60 DSVKTLLLKG KAPVDPECAA KLGKAHVYCE GDDVYDVMLN QTNLQFNNNK YYLIQLLEDD
120 AQRNFSVWMR WGRVGKTGQH SLVTCSGDLN KAKEIFQKKF LDKTKNNWED RENFEKVPGK
180 YDMLQMDYAA STQDESKTKE EETLKPESQL DLRVQELLKL ICNVQTMEEM MIEMKYDTKR
240 APLGKLTVAQ IKAGYQSLKK IEDCIRAGQH GRALVEACNE FYTRIPHDFG LSIPPVIRTE
300 KELSDKVKLL EALGDIEIAL KLVKSERQGL EHPLDQHYRN LHCALRPLDH ESNEFKVISQ
360 YLQSTHAPTH KDYTMTLLDV FEVEKEGEKE AFREDLPNRM LLWHGSRLSN WVGILSHGLR
420 VAPPEAPITG YMFGKGIYFA DMSSKSANYC FASRLKNTGL LLLSEVALGQ CNELLEANPK
480 AQGLLRGKHS TKGMGKMAPS PAHFITLNGS TVPLGPASDT GILNPEGYTL NYNEFIVYSP
540 NQVRMRYLLK IQFNFLQLW
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
201942
Ame J.-C.,Rolli V.,Schreiber V.,Niedergang C.,Apiou F.,Decker P.,Muller S.,Hoeger T.,Menissier-de Murcia J.,de Murcia G.M.
PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase.
J. Biol. Chem.
274
17860-17868
1999
201943
Ame J.-C.,Schreiber V.,Fraulob V.,Dolle P.,de Murcia G.M.,Niedergang C.P.
A bidirectional promoter connects the poly(ADP-ribose) polymerase 2 (PARP-2) gene to the gene for RNase P RNA. Structure and expression of the mouse PARP-2 gene.
J. Biol. Chem.
276
11092-11099
2001
201944
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
201945
Berghammer H.,Ebner M.,Marksteiner R.,Auer B.
pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans.
FEBS Lett.
449
259-263
1999
201946
Schreiber V.,Ame J.-C.,Dolle P.,Schultz I.,Rinaldi B.,Fraulob V.,Menissier-de Murcia J.,de Murcia G.M.
Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1.
J. Biol. Chem.
277
23028-23036
2002
201947
Haenni S.S.,Hassa P.O.,Altmeyer M.,Fey M.,Imhof R.,Hottiger M.O.
Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation.
Int. J. Biochem. Cell Biol.
40
2274-2283
2008
201948
Menissier de Murcia J.,Ricoul M.,Tartier L.,Niedergang C.,Huber A.,Dantzer F.,Schreiber V.,Ame J.C.,Dierich A.,LeMeur M.,Sabatier L.,Chambon P.,de Murcia G.
Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse.
EMBO J.
22
2255-2263
2003
