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Sequence of CP2AD_HUMAN

EC Number:1.14.14.1

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
unspecific monooxygenase
Q16696
Homo sapiens
494
56688
Reaction
RH + [reduced NADPH-hemoprotein reductase] + O2 = ROH + [oxidized NADPH-hemoprotein reductase] + H2O
Other sequences found for EC No. 1.14.14.1

General information:

Sequence
show sequence in fasta format
  0 MLASGLLLVT LLACLTVMVL MSVWRQRKSR GKLPPGPTPL PFIGNYLQLN TEQMYNSLMK
 60 ISERYGPVFT IHLGPRRVVV LCGHDAVKEA LVDQAEEFSG RGEQATFDWL FKGYGVAFSN
120 GERAKQLRRF SIATLRGFGV GKRGIEERIQ EEAGFLIDAL RGTHGANIDP TFFLSRTVSN
180 VISSIVFGDR FDYEDKEFLS LLRMMLGSFQ FTATSTGQLY EMFSSVMKHL PGPQQQAFKE
240 LQGLEDFIAK KVEHNQRTLD PNSPRDFIDS FLIRMQEEEK NPNTEFYLKN LVMTTLNLFF
300 AGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRAKMP YTEAVIHEIQ
360 RFGDMLPMGL AHRVNKDTKF RDFFLPKGTE VFPMLGSVLR DPRFFSNPRD FNPQHFLDKK
420 GQFKKSDAFV PFSIGKRYCF GEGLARMELF LFFTTIMQNF RFKSPQSPKD IDVSPKHVGF
480 ATIPRNYTMS FLPR
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
20228
Fernandez-Salguero P.,Hoffman S.M.,Cholerton S.,Mohrenweiser H.,Raunio H.,Rautio A.,Pelkonen O.,Huang J.D.,Evans W.E.,Idle J.R.
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.
Am. J. Hum. Genet.
57
651-660
1995
20229
Su T.,Bao Z.,Zhang Q.Y.,Smith T.J.,Hong J.Y.,Ding X.
Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Cancer Res.
60
5074-5079
2000
20230
Cauffiez C.,Lo-Guidice J.-M.,Quaranta S.,Allorge D.,Chevalier D.,Cenee S.,Hamdan R.,Lhermitte M.,Lafitte J.-J.,Libersa C.,Colombel J.-F.,Stuecker I.,Broly F.
Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility.
Biochem. Biophys. Res. Commun.
317
662-669
2004
20231
DeVore N.M.,Smith B.D.,Urban M.J.,Scott E.E.
Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymes.
Drug Metab. Dispos.
36
2582-2590
2008
20232
Sansen S.,Hsu M.H.,Stout C.D.,Johnson E.F.
Structural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants.
Arch. Biochem. Biophys.
464
197-206
2007
20233
Smith B.D.,Sanders J.L.,Porubsky P.R.,Lushington G.H.,Stout C.D.,Scott E.E.
Structure of the human lung cytochrome P450 2A13.
J. Biol. Chem.
282
17306-17313
2007
20234
Zhang X.,Su T.,Zhang Q.Y.,Gu J.,Caggana M.,Li H.,Ding X.
Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant.
J. Pharmacol. Exp. Ther.
302
416-423
2002
20235
Fujieda M.,Yamazaki H.,Kiyotani K.,Muroi A.,Kunitoh H.,Dosaka-Akita H.,Sawamura Y.,Kamataki T.
Eighteen novel polymorphisms of the CYP2A13 gene in Japanese.
Drug Metab. Pharmacokinet.
18
86-90
2003
20236
Saito S.,Iida A.,Sekine A.,Kawauchi S.,Higuchi S.,Ogawa C.,Nakamura Y.
Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population.
J. Hum. Genet.
48
249-270
2003