Sequence of AFLQ_ASPPU

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
aflatoxin B synthase
O13345
Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)
528
60189
Reaction
8-O-methyldihydrosterigmatocystin + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 = aflatoxin B2 + 2 [oxidized NADPH-hemoprotein reductase] + H2O + methanol + CO2
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MIYSIIICAG ALLGFLILQK LLAPKDTRPP LPPGPWRKPI IGNLTDFPPK GTPEWLFWAK
 60 HHERYGPMSS LEVMGQTIIM INDAHLGIEI MHKKSALSQM IPDAPFAHMA GWGMSLATER
120 NKQAWKTIRA NMKQEIGTRR AIATFHPKME IGIRRFLLRT LDNPDDLRFH IRKEANAFMM
180 DVAYGYTIAP HGKDELYDLT QQSVRQFSHI FSPGEWSVNF FPILRYVPSW FPGASFQIKA
240 AEYKRTIERM TMVPYLWIKD QVARGCTRPS ILLRLLQKGH YESGSHQEQV LVWTNAEFVM
300 GGSDTTVSAV SSFFVAMALY PEVQHQAREE LDRVVGPTTL ATFEHRSQLP FIDALVKEVF
360 RWHPASPLGA PHITQEDQIW DGYLLPKGAL LLPNIWTFTH DPSVYHDPMV FKPERFLERQ
420 SSPPETDPMK FVFGFGRRIC PGRFVTDEKL FLIACHAISC FLISPKDPGA PEPDWLPGVI
480 SQPGPFDLNV VPRSPAHEEL IRSIETDHPW KNADATDISQ FMARNQMI
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
252734
Yu J.,Chang P.-K.,Ehrlich K.C.,Cary J.W.,Montalbano B.,Dyer J.M.,Bhatnagar D.,Cleveland T.E.
Characterization of the critical amino acids of an Aspergillus parasiticus cytochrome P-450 monooxigenase encoded by ordA that is involved in the biosynthesis of aflatoxins B1, G1, B2, and G2.
Appl. Environ. Microbiol.
64
4834-4841
1998
252735
Yu J.,Chang P.-K.,Bhatnagar D.,Cleveland T.E.
Genes encoding cytochrome P450 and monooxigenase enzymes define one end of the aflatoxin pathway gene cluster in Aspergillus parasiticus.
Appl. Microbiol. Biotechnol.
53
583-590
2000
252736
Yu J.,Bhatnagar D.,Cleveland T.E.
Completed sequence of aflatoxin pathway gene cluster in Aspergillus parasiticus.
FEBS Lett.
564
126-130
2004
252738
Skory C.D.,Chang P.K.,Cary J.,Linz J.E.
Isolation and characterization of a gene from Aspergillus parasiticus associated with the conversion of versicolorin A to sterigmatocystin in aflatoxin biosynthesis.
Appl. Environ. Microbiol.
58
3527-3537
1992
252739
Keller N.P.,Dischinger H.C. Jr.,Bhatnager D.,Cleveland T.E.,Ullah A.H.J.
Purification of a 40-kilodalton methyltransferase active in the aflatoxin biosynthetic pathway.
Appl. Environ. Microbiol.
59
479-484
1993
252740
Yabe K.,Matsuyama Y.,Ando Y.,Nakajima H.,Hamasaki T.
Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin.
Appl. Environ. Microbiol.
59
2486-2492
1993
252741
Yabe K.,Hamasaki T.
Stereochemistry during aflatoxin biosynthesis: cyclase reaction in the conversion of versiconal to versicolorin B and racemization of versiconal hemiacetal acetate.
Appl. Environ. Microbiol.
59
2493-2500
1993
252742
Motomura M.,Chihaya N.,Shinozawa T.,Hamasaki T.,Yabe K.
Cloning and characterization of the O-methyltransferase I gene (dmtA) from Aspergillus parasiticus associated with the conversions of demethylsterigmatocystin to sterigmatocystin and dihydrodemethylsterigmatocystin to dihydrosterigmatocystin in aflatoxin biosynthesis.
Appl. Environ. Microbiol.
65
4987-4994
1999
252743
Zhou R.,Linz J.E.
Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus.
Appl. Environ. Microbiol.
65
5639-5641
1999
252744
Chang P.K.,Yu J.,Ehrlich K.C.,Boue S.M.,Montalbano B.G.,Bhatnagar D.,Cleveland T.E.
adhA in Aspergillus parasiticus is involved in conversion of 5'-hydroxyaverantin to averufin.
Appl. Environ. Microbiol.
66
4715-4719
2000
252745
Hitchman T.S.,Schmidt E.W.,Trail F.,Rarick M.D.,Linz J.E.,Townsend C.A.
Hexanoate synthase, a specialized type I fatty acid synthase in aflatoxin B1 biosynthesis.
Bioorg. Chem.
29
293-307
2001
252746
Udwary D.W.,Casillas L.K.,Townsend C.A.
Synthesis of 11-hydroxyl O-methylsterigmatocystin and the role of a cytochrome P-450 in the final step of aflatoxin biosynthesis.
J. Am. Chem. Soc.
124
5294-5303
2002
252747
Yu J.,Chang P.K.,Ehrlich K.C.,Cary J.W.,Bhatnagar D.,Cleveland T.E.,Payne G.A.,Linz J.E.,Woloshuk C.P.,Bennett J.W.
Clustered pathway genes in aflatoxin biosynthesis.
Appl. Environ. Microbiol.
70
1253-1262
2004
252748
Ehrlich K.C.,Chang P.K.,Yu J.,Cotty P.J.
Aflatoxin biosynthesis cluster gene cypA is required for G aflatoxin formation.
Appl. Environ. Microbiol.
70
6518-6524
2004
252749
Sakuno E.,Wen Y.,Hatabayashi H.,Arai H.,Aoki C.,Yabe K.,Nakajima H.
Aspergillus parasiticus cyclase catalyzes two dehydration steps in aflatoxin biosynthesis.
Appl. Environ. Microbiol.
71
2999-3006
2005
252750
Ehrlich K.C.,Montalbano B.,Boue S.M.,Bhatnagar D.
An aflatoxin biosynthesis cluster gene encodes a novel oxidase required for conversion of versicolorin a to sterigmatocystin.
Appl. Environ. Microbiol.
71
8963-8965
2005
252751
Henry K.M.,Townsend C.A.
Ordering the reductive and cytochrome P450 oxidative steps in demethylsterigmatocystin formation yields general insights into the biosynthesis of aflatoxin and related fungal metabolites.
J. Am. Chem. Soc.
127
3724-3733
2005
252752
Cary J.W.,Ehrlich K.C.,Bland J.M.,Montalbano B.G.
The aflatoxin biosynthesis cluster gene, aflX, encodes an oxidoreductase involved in conversion of versicolorin A to demethylsterigmatocystin.
Appl. Environ. Microbiol.
72
1096-1101
2006
252753
Cai J.,Zeng H.,Shima Y.,Hatabayashi H.,Nakagawa H.,Ito Y.,Adachi Y.,Nakajima H.,Yabe K.
Involvement of the nadA gene in formation of G-group aflatoxins in Aspergillus parasiticus.
Fungal Genet. Biol.
45
1081-1093
2008
252754
Crawford J.M.,Thomas P.M.,Scheerer J.R.,Vagstad A.L.,Kelleher N.L.,Townsend C.A.
Deconstruction of iterative multidomain polyketide synthase function.
Science
320
243-246
2008